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. 1994 Jul 9;309(6947):83–86. doi: 10.1136/bmj.309.6947.83

Changes in long term prognosis for breast cancer in a Dutch cancer registry.

H W Nab 1, W C Hop 1, M A Crommelin 1, H M Kluck 1, L H van der Heijden 1, J W Coebergh 1
PMCID: PMC2540542  PMID: 8038671

Abstract

OBJECTIVES--To assess whether the long term survival of patients with breast cancer has changed with time. DESIGN--Population based descriptive study. SETTING--Eindhoven Cancer Registry in south east Netherlands. SUBJECTS--2052 patients with first primary breast cancer diagnosed between 1955 and 1974. MAIN OUTCOME MEASURES--Overall survival and relative survival. RESULTS--Overall survival was 35% (727 patients) after 10 years, 21% (267) after 20 years, and 15% (25) after 30 years. The corresponding relative survival rates were 43%, 34%, and 34%, respectively. Survival improved from 1955 onwards for all ages and all tumour stages. Improvement was observed in both overall and relative survival. Prognosis was strongly related to the stage at diagnosis in the first 10 years of follow up but independent of stage after 10 years. Survival of patients still alive after 19 years became similar to that of the general female population. CONCLUSIONS--Both short and long term survival improved considerably in all age groups. This improvement was most marked for patients who were diagnosed with a localised tumour. Patients who survive for 19 years may be considered cured.

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Selected References

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  1. Adami H. O., Malker B., Rutqvist L. E., Persson I., Ries L. Temporal trends in breast cancer survival in Sweden: significant improvement in 20 years. J Natl Cancer Inst. 1986 Apr;76(4):653–659. doi: 10.1093/jnci/76.4.653. [DOI] [PubMed] [Google Scholar]
  2. BERKSON J., GAGE R. P. Calculation of survival rates for cancer. Proc Staff Meet Mayo Clin. 1950 May 24;25(11):270–286. [PubMed] [Google Scholar]
  3. Cascinelli N., Greco M., Morabito A., Bufalino R., Testori A., Baldini M. T., Andreola S., Leo E., Galluzzo D., Rilke F. Comparison of long-term survival of 1986 consecutive patients with breast cancer treated at the National Cancer Institute of Milano, Italy (1971 to 1972 and 1977 to 1978). Cancer. 1991 Jul 15;68(2):427–434. doi: 10.1002/1097-0142(19910715)68:2<427::aid-cncr2820680236>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
  4. Caygill C. P., Hill M. J. Trends in European breast cancer incidence and possible etiology. Tumori. 1991 Apr 30;77(2):126–129. doi: 10.1177/030089169107700207. [DOI] [PubMed] [Google Scholar]
  5. Danforth D. N., Jr, Findlay P. A., McDonald H. D., Lippman M. E., Reichert C. M., d'Angelo T., Gorrell C. R., Gerber N. L., Lichter A. S., Rosenberg S. A. Complete axillary lymph node dissection for stage I-II carcinoma of the breast. J Clin Oncol. 1986 May;4(5):655–662. doi: 10.1200/JCO.1986.4.5.655. [DOI] [PubMed] [Google Scholar]
  6. Duncan W., Kerr G. R. The curability of breast cancer. Br Med J. 1976 Oct 2;2(6039):781–783. doi: 10.1136/bmj.2.6039.781. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Feinstein A. R., Sosin D. M., Wells C. K. The Will Rogers phenomenon. Stage migration and new diagnostic techniques as a source of misleading statistics for survival in cancer. N Engl J Med. 1985 Jun 20;312(25):1604–1608. doi: 10.1056/NEJM198506203122504. [DOI] [PubMed] [Google Scholar]
  8. Greenough A., Wood S., Morley C. J., Davis J. A. Pancuronium prevents pneumothoraces in ventilated premature babies who actively expire against positive pressure inflation. Lancet. 1984 Jan 7;1(8367):1–3. doi: 10.1016/s0140-6736(84)90177-6. [DOI] [PubMed] [Google Scholar]
  9. Hakulinen T. Cancer survival corrected for heterogeneity in patient withdrawal. Biometrics. 1982 Dec;38(4):933–942. [PubMed] [Google Scholar]
  10. Hibberd A. D., Horwood L. J., Wells J. E. Long term prognosis of women with breast cancer in New Zealand: study of survival to 30 years. Br Med J (Clin Res Ed) 1983 Jun 4;286(6380):1777–1779. doi: 10.1136/bmj.286.6380.1777. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Joensuu H., Toikkanen S. Comparison of breast carcinomas diagnosed in the 1980s with those diagnosed in the 1940s to 1960s. BMJ. 1991 Jul 20;303(6795):155–158. doi: 10.1136/bmj.303.6795.155. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. La Vecchia C., Lucchini F., Negri E., Boyle P., Maisonneuve P., Levi F. Trends of cancer mortality in Europe, 1955-1989: III, Breast and genital sites. Eur J Cancer. 1992;28A(4-5):927–998. doi: 10.1016/0959-8049(92)90153-s. [DOI] [PubMed] [Google Scholar]
  13. Langlands A. O., Pocock S. J., Kerr G. R., Gore S. M. Long-term survival of patients with breast cancer: a study of the curability of the disease. Br Med J. 1979 Nov 17;2(6200):1247–1251. doi: 10.1136/bmj.2.6200.1247. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Miller B. A., Feuer E. J., Hankey B. F. Recent incidence trends for breast cancer in women and the relevance of early detection: an update. CA Cancer J Clin. 1993 Jan-Feb;43(1):27–41. doi: 10.3322/canjclin.43.1.27. [DOI] [PubMed] [Google Scholar]
  15. Nab H. W., Mulder P. G., Crommelin M. A., vd Heijden L. H., Coebergh J. W. Is the peak in breast cancer incidence in sight? A study conducted in the southeastern Netherlands. Eur J Cancer. 1994;30A(1):50–52. doi: 10.1016/s0959-8049(05)80018-8. [DOI] [PubMed] [Google Scholar]
  16. Nab H. W., Voogd A. C., Crommelin M. A., Kluck H. M., vd Heijden L. H., Coebergh J. W. Breast cancer in the southeastern Netherlands, 1960-1989: trends in incidence and mortality. Eur J Cancer. 1993;29A(11):1557–1559. doi: 10.1016/0959-8049(93)90294-p. [DOI] [PubMed] [Google Scholar]
  17. Rutqvist L. E., Wallgren A. Long-term survival of 458 young breast cancer patients. Cancer. 1985 Feb 1;55(3):658–665. doi: 10.1002/1097-0142(19850201)55:3<658::aid-cncr2820550331>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  18. Saarela E. Autotransfusion; a review. Ann Clin Res. 1981;13 (Suppl 33):48–56. [PubMed] [Google Scholar]

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