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. 1987 Apr;61(4):1271–1275. doi: 10.1128/jvi.61.4.1271-1275.1987

Mapping and sequencing of a gene from myxoma virus that is related to those encoding epidermal growth factor and transforming growth factor alpha.

C Upton, J L Macen, G McFadden
PMCID: PMC254093  PMID: 3029424

Abstract

Myxoma virus, a Leporipoxvirus and agent of myxomatosis, was shown to possess a gene with the potential to encode an epidermal growth factorlike factor. Its relationship to other members of this family, including the poxvirus growth factors from Shope fibroma virus and vaccinia virus, was analyzed. Alignment of DNA sequences and related open reading frames of myxoma virus and Shope fibroma virus indicated colinearity of genes between these poxviruses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blomquist M. C., Hunt L. T., Barker W. C. Vaccinia virus 19-kilodalton protein: relationship to several mammalian proteins, including two growth factors. Proc Natl Acad Sci U S A. 1984 Dec;81(23):7363–7367. doi: 10.1073/pnas.81.23.7363. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brown J. P., Twardzik D. R., Marquardt H., Todaro G. J. Vaccinia virus encodes a polypeptide homologous to epidermal growth factor and transforming growth factor. Nature. 1985 Feb 7;313(6002):491–492. doi: 10.1038/313491a0. [DOI] [PubMed] [Google Scholar]
  3. Brown S. T., Nalley J. F., Kraus S. J. Molluscum contagiosum. Sex Transm Dis. 1981 Jul-Sep;8(3):227–234. doi: 10.1097/00007435-198107000-00012. [DOI] [PubMed] [Google Scholar]
  4. Chang W., Upton C., Hu S. L., Purchio A. F., McFadden G. The genome of Shope fibroma virus, a tumorigenic poxvirus, contains a growth factor gene with sequence similarity to those encoding epidermal growth factor and transforming growth factor alpha. Mol Cell Biol. 1987 Jan;7(1):535–540. doi: 10.1128/mcb.7.1.535. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Delange A. M., Macaulay C., Block W., Mueller T., McFadden G. Tumorigenic poxviruses: construction of the composite physical map of the Shope fibroma virus genome. J Virol. 1984 May;50(2):408–416. doi: 10.1128/jvi.50.2.408-416.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Fenner F. The Florey lecture, 1983. Biological control, as exemplified by smallpox eradication and myxomatosis. Proc R Soc Lond B Biol Sci. 1983 Jun 22;218(1212):259–285. doi: 10.1098/rspb.1983.0039. [DOI] [PubMed] [Google Scholar]
  7. Henikoff S. Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. Gene. 1984 Jun;28(3):351–359. doi: 10.1016/0378-1119(84)90153-7. [DOI] [PubMed] [Google Scholar]
  8. King C. S., Cooper J. A., Moss B., Twardzik D. R. Vaccinia virus growth factor stimulates tyrosine protein kinase activity of A431 cell epidermal growth factor receptors. Mol Cell Biol. 1986 Jan;6(1):332–336. doi: 10.1128/mcb.6.1.332. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Reisner A. H. Similarity between the vaccinia virus 19K early protein and epidermal growth factor. 1985 Feb 28-Mar 6Nature. 313(6005):801–803. doi: 10.1038/313801a0. [DOI] [PubMed] [Google Scholar]
  10. Rohrmann G., Yuen L., Moss B. Transcription of vaccinia virus early genes by enzymes isolated from vaccinia virions terminates downstream of a regulatory sequence. Cell. 1986 Sep 26;46(7):1029–1035. doi: 10.1016/0092-8674(86)90702-6. [DOI] [PubMed] [Google Scholar]
  11. Sanger F., Nicklen S., Coulson A. R. DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463–5467. doi: 10.1073/pnas.74.12.5463. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Strayer D. S., Cabirac G., Sell S., Leibowitz J. L. Malignant rabbit fibroma virus: observations on the culture and histopathologic characteristics of a new virus-induced rabbit tumor. J Natl Cancer Inst. 1983 Jul;71(1):91–104. [PubMed] [Google Scholar]
  13. Strayer D. S., Sell S. Immunohistology of malignant rabbit fibroma virus--a comparative study with rabbit myxoma virus. J Natl Cancer Inst. 1983 Jul;71(1):105–116. [PubMed] [Google Scholar]
  14. Stroobant P., Rice A. P., Gullick W. J., Cheng D. J., Kerr I. M., Waterfield M. D. Purification and characterization of vaccinia virus growth factor. Cell. 1985 Aug;42(1):383–393. doi: 10.1016/s0092-8674(85)80133-1. [DOI] [PubMed] [Google Scholar]
  15. Twardzik D. R., Brown J. P., Ranchalis J. E., Todaro G. J., Moss B. Vaccinia virus-infected cells release a novel polypeptide functionally related to transforming and epidermal growth factors. Proc Natl Acad Sci U S A. 1985 Aug;82(16):5300–5304. doi: 10.1073/pnas.82.16.5300. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Upton C., McFadden G. Identification and nucleotide sequence of the thymidine kinase gene of Shope fibroma virus. J Virol. 1986 Dec;60(3):920–927. doi: 10.1128/jvi.60.3.920-927.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Upton C., McFadden G. Tumorigenic poxviruses: analysis of viral DNA sequences implicated in the tumorigenicity of Shope fibroma virus and malignant rabbit virus. Virology. 1986 Jul 30;152(2):308–321. doi: 10.1016/0042-6822(86)90134-0. [DOI] [PubMed] [Google Scholar]
  18. Vieira J., Messing J. The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. Gene. 1982 Oct;19(3):259–268. doi: 10.1016/0378-1119(82)90015-4. [DOI] [PubMed] [Google Scholar]
  19. Wills A., Delange A. M., Gregson C., Macaulay C., McFadden G. Physical characterization and molecular cloning of the Shope fibroma virus DNA genome. Virology. 1983 Oct 30;130(2):403–414. doi: 10.1016/0042-6822(83)90095-8. [DOI] [PubMed] [Google Scholar]
  20. Yuen L., Moss B. Multiple 3' ends of mRNA encoding vaccinia virus growth factor occur within a series of repeated sequences downstream of T clusters. J Virol. 1986 Oct;60(1):320–323. doi: 10.1128/jvi.60.1.320-323.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]

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