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. 1987 Apr;61(4):1282–1285. doi: 10.1128/jvi.61.4.1282-1285.1987

Deletion mutations in the small t antigen gene alter the tissue specificity of tumors induced by simian virus 40.

B J Matthews, A S Levine, K Dixon
PMCID: PMC254095  PMID: 3029426

Abstract

Subcutaneous injection of wild-type simian virus 40 into Syrian hamsters normally induces fibrosarcomas at the injection site. We showed that subcutaneous injection of three different small t deletion mutants (dl884, dl883, and dl890) led to the formation of abdominal reticulum cell sarcomas (lymphomas) in about 15% of the animals bearing tumors. The remainder of the tumors were fibrosarcomas occurring with prolonged latencies at the site of injection. We postulated that, in the absence of an active small t protein, which is thought to have cell growth-promoting properties, the mutant virus preferentially transforms rapidly proliferating lymphoid cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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