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. 1994 Sep 10;309(6955):636–638. doi: 10.1136/bmj.309.6955.636

Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study.

J Kuusisto 1, K Koivisto 1, K Kervinen 1, L Mykkänen 1, E L Helkala 1, M Vanhanen 1, T Hänninen 1, K Pyörälä 1, Y A Kesäniemi 1, P Riekkinen 1, et al.
PMCID: PMC2541512  PMID: 8086986

Abstract

OBJECTIVE--To determine the association between the e4 allele of apolipoprotein E and Alzheimer's disease in a randomly selected population sample. DESIGN--Cross sectional population based study. SUBJECTS--980 people aged 69 to 78 (349 men, 631 women). SETTING--Population of Kuopio, eastern Finland. MAIN OUTCOME MEASURES--Presence of e4 allele and diagnosis of Alzheimer's disease by detailed neurological and neurophysiological evaluation. RESULTS--46 (4.7%) subjects were classified as having probable or possible Alzheimer's disease. The frequency of the apolipoprotein E e4 allele was 0.359 in patients with Alzheimer's disease and 0.165 subjects without dementia (P < 0.0001). The prevalence of Alzheimer's disease was 2.9% in subjects with no e4 alleles, 7.6% in subjects with one e4 allele, and 21.4% in subjects with two e4 alleles of apolipoprotein E. CONCLUSIONS--Allele e4 of apolipoprotein is associated with Alzheimer's disease in a dose-response fashion in a randomly selected elderly population.

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Selected References

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