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. 1953;9(2):175–182.

The physiology of iodine *,†

Beverly T Towery
PMCID: PMC2542103  PMID: 13094506

Abstract

The history of work on the physiology of iodine is traced, and the rapid advances of the past quarter of a century described. In considering the application of these discoveries and of recently-developed techniques to problems of thyroid function and the treatment of hyperthyroidism, the author examines the mechanism of the iodide trap and the role of iodide in the biosynthesis of hormones. The kinetics of hormone release, the nature of the circulating thyroid hormone, and hormonal metabolism are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALBERT A., TENNEY A. Effect of iodide, thiouracil and thyroxine on the disappearance of thyroidal I131. Proc Soc Exp Biol Med. 1951 Jun;77(2):202–203. doi: 10.3181/00379727-77-18723. [DOI] [PubMed] [Google Scholar]
  2. DANOWSKI T. S., JOHNSTON S. Y., PRICE W. C., McKELVY M., STEVENSON S. S., McCLUSKEY E. R. Protein-bound iodine in infants from birth to one year of age. Pediatrics. 1951 Feb;7(2):240–244. [PubMed] [Google Scholar]
  3. GROSS J., LEBLOND C. P. The presence of free iodinated compounds in the thyroid and their passage into the circulation. Endocrinology. 1951 Jun;48(6):714–725. doi: 10.1210/endo-48-6-714. [DOI] [PubMed] [Google Scholar]
  4. GROSS J., PITT-RIVERS R. Physiological activity of 3:5:3'-L-triiodothyronine. Lancet. 1952 Mar 22;1(6708):593–594. doi: 10.1016/s0140-6736(52)90104-9. [DOI] [PubMed] [Google Scholar]
  5. GROSS J., PITT-RIVERS R., TROTTER W. R. Effect of 3:5:3'-L-triiodothyronine in myxoedema. Lancet. 1952 May 24;1(6717):1044–1045. doi: 10.1016/s0140-6736(52)90695-8. [DOI] [PubMed] [Google Scholar]
  6. GROSS J., PITT-RIVERS R. The identification of 3:5:3'-L-triiodothyronine in human plasma. Lancet. 1952 Mar 1;1(6705):439–441. doi: 10.1016/s0140-6736(52)91952-1. [DOI] [PubMed] [Google Scholar]
  7. Harington C. R., Barger G. Chemistry of Thyroxine: Constitution and Synthesis of Thyroxine. Biochem J. 1927;21(1):169–183. doi: 10.1042/bj0210169. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. LEVINE M. D. Mucolytic activity of the thyroid gland. J Endocrinol. 1950 Jan;6(3):288-92, pl. doi: 10.1677/joe.0.0060288. [DOI] [PubMed] [Google Scholar]
  9. Murray G. R. Note on the Treatment of Myxoedema by Hypodermic Injections of an Extract of the Thyroid Gland of a Sheep. Br Med J. 1891 Oct 10;2(1606):796–797. doi: 10.1136/bmj.2.1606.796. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. PITT-RIVERS R. Mode of action of antithyroid compounds. Physiol Rev. 1950 Apr;30(2):194–195. doi: 10.1152/physrev.1950.30.2.194. [DOI] [PubMed] [Google Scholar]
  11. RANDALL R. V., LORENZ N., ALBERT A. The effect of hypophysectomy on the biologic decay of thyroidal radioiodine. Endocrinology. 1951 Mar;48(3):339–340. doi: 10.1210/endo-48-3-339. [DOI] [PubMed] [Google Scholar]
  12. ROCHE J., LISSITZKY S., MICHEL R. Caractérisation de la monoiodohistidine et de la diiodothyronine dans la thyroglobuline marquée. C R Hebd Seances Acad Sci. 1951 May 28;232(22):2047–2049. [PubMed] [Google Scholar]
  13. STANBURY J. B., BROWNELL G. L., RIGGS D. S., PERINETTI H., DEL CASTILLO E., ITOIZ J., HOUSSAY A., TRUCCO E., YACIOFANO A. C. The iodine-deficient human thyroid gland; a preliminary report. J Clin Endocrinol Metab. 1952 Feb;12(2):191–207. doi: 10.1210/jcem-12-2-191. [DOI] [PubMed] [Google Scholar]
  14. STANBURY J. B. Cretinism with goiter; a case report. J Clin Endocrinol Metab. 1951 Jul;11(7):740–742. doi: 10.1210/jcem-11-7-740. [DOI] [PubMed] [Google Scholar]
  15. STANBURY J. B., HEDGE A. N. A study of a family of goitrous cretins. J Clin Endocrinol Metab. 1950 Nov;10(11):1471–1484. doi: 10.1210/jcem-10-11-1471. [DOI] [PubMed] [Google Scholar]
  16. WOOD J. L., KINGSLAND N. Labeled sulfur uptake by thyroids of rats with low plasma thiocyanate levels. J Biol Chem. 1950 Aug;185(2):833–837. [PubMed] [Google Scholar]
  17. WYNGAARDEN J. B., STANBURY J. B., DuTOIT C. H. On the mechanism of iodide accumulation by the thyroid gland. J Clin Endocrinol Metab. 1951 Nov;11(11):1259–1272. doi: 10.1210/jcem-11-11-1259. [DOI] [PubMed] [Google Scholar]

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