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. 1954;10(4):619–626.

Treatment of early infectious syphilis with N,N′-dibenzylethylenediamine dipenicillin G*

A second report

James K Shafer, Clarence A Smith
PMCID: PMC2542153  PMID: 13182589

Abstract

A new penicillin salt—N,N′-dibenzylethylenediamine dipenicillin G (Bicillin)a—was given, in single injections of 2,500,000 units, to 196 patients with early infectious syphilis. The seronegativity rates after three months were 65% for primary syphilis cases and 25% for secondary syphilis patients; after six months, the rates were 80% and 60%, respectively. At the end of the 21-month observation period, satisfactory results were recorded in 96.6%-100.0% of the primary syphilis patients, and in 92%-95% of those treated for secondary syphilis. The respective cumulative re-treatment rates were 3.4% and 4.1%.

The results of the secondary syphilis treatment were then compared with those obtained with single-injection schedules of 2,400,000 and 4,800,000 units of procaine penicillin G in oil with 2% aluminium monostearate (PAM). The cumulative re-treatment rates 21 months after treatment were: Bicillin, 4.1%; PAM (2.4 million units), 14.2%; and PAM (4.8 million units), 5.1%. It would thus appear that a single injection of 2,500,000 units of Bicillin is as effective as one of 4,800,000 units of PAM.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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