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. Author manuscript; available in PMC: 2009 Jul 31.
Published in final edited form as: Pain. 2008 Feb 20;137(3):540–549. doi: 10.1016/j.pain.2007.10.017

Figure 5. Intrathecally administered PKA inhibitors attenuated the effect of estradiol.

Figure 5

A: the time course of the effect of intrathecally injected Rp-8-Br-cAMP (200 nmol) on the visceromotor response (VMR) to CRD in OVx and E2 rats. b: baseline. * p<0.05, **p<0.01 vs. baseline response in E2 rats. B: the visceromotor response to CRD was atttenuated by Rp-8-Br-cAMP (Rp), but not vehicle in E2 rats. # p<0.05 vs. saline treated group. * p<0.05, ** p<0.01 vs. same time point in saline group. C: representative Western blots (left) and quantification of Western blot data (right) showing Rp-8-Br-cAMP attenuated the phosphorylation of NR1 ser-897 in the rats shown in B. Values represent the pNR1/NR1 ratio normalized to saline treated rats. * p<0.01. D, E: the peak attenuation of the visceromotor response by intrathecal H-89 (D) or chelerythrine chloride (E) compared to the appropriate vehicle (V). * p<0.05 vs. vehicle.