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. 1984 Jul;51(1):233–236. doi: 10.1128/jvi.51.1.233-236.1984

A murine model for oral infection with a primate rotavirus (simian SA11).

P A Offit, H F Clark, M J Kornstein, S A Plotkin
PMCID: PMC254422  PMID: 6328042

Abstract

Simian rotavirus SA11 was shown to replicate in the gastrointestinal tracts of infant mice after oral inoculation. Clinical symptoms, histopathological changes in the small intestinal mucosa, and the type-specific humoral immune response were all characteristic of rotavirus-induced gastroenteritis. The availability of this small animal model for the study of a primate rotavirus infection should expedite analysis of the immune response necessary for protection against challenge.

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Selected References

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