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. 1984 Aug;51(2):567–569. doi: 10.1128/jvi.51.2.567-569.1984

Mutations in the hemagglutinin receptor-binding site can change the biological properties of an influenza virus.

C W Naeve, V S Hinshaw, R G Webster
PMCID: PMC254476  PMID: 6748165

Abstract

Avian influenza virus reassortants containing human influenza virus hemagglutinins do not replicate in ducks. Two mutations in the receptor-binding site of a human hemagglutinin at residues 226 and 228 allowed replication in ducks. The mutations resulted in a receptor-binding-site sequence identical to the known avian influenza virus sequences.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Air G. M. Nucleotide sequence coding for the "signal peptide" and N terminus of the hemagglutinin from an asian (H2N2) strain of influenza virus. Virology. 1979 Sep;97(2):468–472. doi: 10.1016/0042-6822(79)90358-1. [DOI] [PubMed] [Google Scholar]
  2. Both G. W., Shi C. H., Kilbourne E. D. Hemagglutinin of swine influenza virus: a single amino acid change pleiotropically affects viral antigenicity and replication. Proc Natl Acad Sci U S A. 1983 Nov;80(22):6996–7000. doi: 10.1073/pnas.80.22.6996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Naeve C. W., Webster R. G., Hinshaw V. S. Phenotypic variation in influenza virus reassortants with identical gene constellations. Virology. 1983 Jul 30;128(2):331–340. doi: 10.1016/0042-6822(83)90260-x. [DOI] [PubMed] [Google Scholar]
  4. Naeve C. W., Webster R. G. Sequence of the hemagglutinin gene from influenza virus A/Seal/Mass/1/80. Virology. 1983 Sep;129(2):298–308. doi: 10.1016/0042-6822(83)90169-1. [DOI] [PubMed] [Google Scholar]
  5. Porter A. G., Barber C., Carey N. H., Hallewell R. A., Threlfall G., Emtage J. S. Complete nucleotide sequence of an influenza virus haemagglutinin gene from cloned DNA. Nature. 1979 Nov 29;282(5738):471–477. doi: 10.1038/282471a0. [DOI] [PubMed] [Google Scholar]
  6. Rogers G. N., Paulson J. C., Daniels R. S., Skehel J. J., Wilson I. A., Wiley D. C. Single amino acid substitutions in influenza haemagglutinin change receptor binding specificity. Nature. 1983 Jul 7;304(5921):76–78. doi: 10.1038/304076a0. [DOI] [PubMed] [Google Scholar]
  7. Sanger F., Nicklen S., Coulson A. R. DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463–5467. doi: 10.1073/pnas.74.12.5463. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Schild G. C., Oxford J. S., de Jong J. C., Webster R. G. Evidence for host-cell selection of influenza virus antigenic variants. Nature. 1983 Jun 23;303(5919):706–709. doi: 10.1038/303706a0. [DOI] [PubMed] [Google Scholar]
  9. Ward C. W., Dopheide T. A. Evolution of the Hong Kong influenza A sub-type. Structural relationships between the haemagglutinin from A/duck/Ukraine/1/63 (Hav 7) and the Hong Kong (H3) haemagglutinins. Biochem J. 1981 Apr 1;195(1):337–340. doi: 10.1042/bj1950337. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Webster R. G., Yakhno M., Hinshaw V. S., Bean W. J., Murti K. G. Intestinal influenza: replication and characterization of influenza viruses in ducks. Virology. 1978 Feb;84(2):268–278. doi: 10.1016/0042-6822(78)90247-7. [DOI] [PMC free article] [PubMed] [Google Scholar]

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