Abstract
A 75 g oral glucose tolerance test was performed in 212 pregnant women with no predisposing factors suggesting glucose intolerance to establish the normal pattern of glucose metabolism in pregnancy. Reference values for the test were established for the middle of pregnancy (14-20 weeks, n=43) and late pregnancy (28-37 weeks, n=168). One woman was excluded because she had diabetes that required treatment with insulin. There were statistically significant differences between the two groups for samples taken both one and two hours after the glucose load. Reference ranges for the interpretation of the glucose tolerance test in pregnancy should therefore take account of the period of gestation.
Arbitrary upper limits of normal (represented by the 97·5 centile) two hours after a 75 g oral glucose load are proposed at 7·5 and 9·6 mmol/l for the second and third trimesters, respectively.
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- Abell D. A., Beischer N. A. Evaluation of the three-hour oral glucose tolerance test in detection of significant hyperglycemia and hypoglycemia in pregnancy. Diabetes. 1975 Oct;24(10):874–880. doi: 10.2337/diab.24.10.874. [DOI] [PubMed] [Google Scholar]
- JACKSON W. P. Is pregnancy diabetogenic? Lancet. 1961 Dec 23;2(7217):1369–1372. doi: 10.1016/s0140-6736(61)91195-3. [DOI] [PubMed] [Google Scholar]
- Kühl C. Glucose metabolism during and after pregnancy in normal and gestational diabetic women. 1. Influence of normal pregnancy on serum glucose and insulin concentration during basal fasting conditions and after a challenge with glucose. Acta Endocrinol (Copenh) 1975 Aug;79(4):709–719. [PubMed] [Google Scholar]
- Lind T., Billewicz W. Z., Brown G. A serial study of changes occurring in the oral glucose tolerance test during pregnancy. J Obstet Gynaecol Br Commonw. 1973 Dec;80(12):1033–1039. doi: 10.1111/j.1471-0528.1973.tb02976.x. [DOI] [PubMed] [Google Scholar]
- O'SULLIVAN J. B., MAHAN C. M. CRITERIA FOR THE ORAL GLUCOSE TOLERANCE TEST IN PREGNANCY. Diabetes. 1964 May-Jun;13:278–285. [PubMed] [Google Scholar]