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. 1984 Nov;52(2):431–435. doi: 10.1128/jvi.52.2.431-435.1984

Fine structure analysis of type-specific and type-common antigenic sites of herpes simplex virus glycoprotein D.

B Dietzschold, R J Eisenberg, M Ponce de Leon, E Golub, F Hudecz, A Varrichio, G H Cohen
PMCID: PMC254543  PMID: 6208376

Abstract

The fine structure of the antigenic determinants of herpes simplex virus type 1 and 2 glycoprotein D (gD) was analyzed to determine whether structural differences underlie the differential immunogenicity of these glycoproteins. A region common to herpes simplex virus type 1 and 2 gD (amino acid residues 11 to 19) and two sites specific for herpes simplex virus type 2 gD (one determined by proline at position 7, the other determined by asparagine at position 21) were localized within the N-terminal 23 amino acids of gD by synthesis of peptides and comparison of their cross-reactivity with antisera raised to herpes simplex virus type 1 and 2 gD. The secondary structure of these peptides, as predicted by computer analysis, is discussed in relation to their immunogenicity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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