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. 1984 Nov;52(2):687–690. doi: 10.1128/jvi.52.2.687-690.1984

Adenovirus 12 nononcogenic mutants: oncogenicity of transformed cells and viral proteins synthesized in vivo and in vitro.

I Mak, H Galet, S Mak
PMCID: PMC254575  PMID: 6492258

Abstract

Several nononcogenic cyt mutants of adenovirus type 12 induced the same E1A (55,000 [55K] and 25K) and E1B polypeptides (55K, 19K, and 17K) as did the wild-type virus, except that cyt 68 did not induce the E1B 19K protein. Tumorigenicity tests showed cells transformed by cyt 68 to be highly oncogenic in vivo. Therefore, it was concluded that the E1B 19K polypeptide is not necessary for tumor induction but may be involved in the efficiency of transformation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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