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. 1988 May 7;296(6632):1295–1298. doi: 10.1136/bmj.296.6632.1295

Prevalence, concentration, and prognostic importance of proteinuria in patients with malignancies

Nick Sawyer, Jane Wadsworth, Marc Wijnen, Roger Gabriel
PMCID: PMC2545767  PMID: 3133055

Abstract

Protein was found significantly more frequently in single urine samples from 504 patients with malignancy (290; 58%) than in 529 controls (119; 22%) (p<0·001). Median protein concentration was greater (p<0·001) in patients with neoplasia (0·14 g/l) than in controls (0·07 g/l). Actuarial analysis showed a median survival of 4·5 months in patients with proteinuria compared with 10 months in those without (p<0·001). The association between proteinuria and shorter survival was statistically significant for patients with gut tumours, lung tumours, and tumours at other sites analysed as a group. Patients with myeloma or urinary tract tumours were not studied.

In many patients with malignancy the presence of proteinuria may be associated with a substantially reduced survival time.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Balant L. P., Fabre J. Clinical significance of proteinuria. Compr Ther. 1978 Oct;4(10):54–62. [PubMed] [Google Scholar]
  2. Beaufils H., Jouanneau C., Chomette G. Kidney and cancer: results of immunofluorescence microscopy. Nephron. 1985;40(3):303–308. doi: 10.1159/000183483. [DOI] [PubMed] [Google Scholar]
  3. Costanza M. E., Pinn V., Schwartz R. S., Nathanson L. Carcinoembryonic antigen-antibody complexes in a patient with colonic carcinoma and nephrotic syndrome. N Engl J Med. 1973 Sep 6;289(10):520–522. doi: 10.1056/NEJM197309062891007. [DOI] [PubMed] [Google Scholar]
  4. Couser W. G., Wagonfeld J. B., Spargo B. H., Lewis E. J. Glomerular deposition of tumor antigen in membranous nephropathy associated with colonic carcinoma. Am J Med. 1974 Dec;57(6):962–970. doi: 10.1016/0002-9343(74)90176-4. [DOI] [PubMed] [Google Scholar]
  5. Eagen J. W. Glomerulopathies of neoplasia. Kidney Int. 1977 May;11(5):297–303. doi: 10.1038/ki.1977.47. [DOI] [PubMed] [Google Scholar]
  6. Ghosh L., Muehrcke R. C. Nephrotic syndrome: a prodrome to lymphoma. Ann Intern Med. 1970 Mar;72(3):379–382. doi: 10.7326/0003-4819-72-3-379. [DOI] [PubMed] [Google Scholar]
  7. Ginsberg J. M., Chang B. S., Matarese R. A., Garella S. Use of single voided urine samples to estimate quantitative proteinuria. N Engl J Med. 1983 Dec 22;309(25):1543–1546. doi: 10.1056/NEJM198312223092503. [DOI] [PubMed] [Google Scholar]
  8. Gosling P., Sutcliffe A. J. Proteinuria following trauma. Ann Clin Biochem. 1986 Nov;23(Pt 6):681–685. doi: 10.1177/000456328602300610. [DOI] [PubMed] [Google Scholar]
  9. Kannel W. B., Stampfer M. J., Castelli W. P., Verter J. The prognostic significance of proteinuria: the Framingham study. Am Heart J. 1984 Nov;108(5):1347–1352. doi: 10.1016/0002-8703(84)90763-4. [DOI] [PubMed] [Google Scholar]
  10. Kaplan B. S., Klassen J., Gault M. H. Glomerular injury in patients with neoplasia. Annu Rev Med. 1976;27:117–125. doi: 10.1146/annurev.me.27.020176.001001. [DOI] [PubMed] [Google Scholar]
  11. Moorthy A. V., Zimmerman S. W., Burkholder P. M. Nephrotic syndrome in Hodgkin's disease. Evidence for pathogenesis alternative to immune complex deposition. Am J Med. 1976 Oct;61(4):471–477. doi: 10.1016/0002-9343(76)90325-9. [DOI] [PubMed] [Google Scholar]
  12. Olson J. L., Philips T. M., Lewis M. G., Solez K. Malignant melanoma with renal dense deposits containing tumor antigens. Clin Nephrol. 1979 Aug;12(2):74–82. [PubMed] [Google Scholar]
  13. Pascal R. R., Iannaccone P. M., Rollwagen F. M., Harding T. A., Bennett S. J. Electron microscopy and immunofluorescence of glomerular immune complex deposits in cancer patients. Cancer Res. 1976 Jan;36(1):43–47. [PubMed] [Google Scholar]
  14. Sinclair R. A., Burns J., Dunnill M. S. Immunoperoxidase staining of formalin-fixed, paraffin-embedded, human renal biopsies with a comparison of the peroxidase-antiperoxidase (PAP) and indirect methods. J Clin Pathol. 1981 Aug;34(8):859–865. doi: 10.1136/jcp.34.8.859. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Sutherland J. C., Markham R. V., Jr, Mardiney M. R., Jr Subclinical immune complexes in the glomeruli of kidneys postmortem. Am J Med. 1974 Oct;57(4):536–541. doi: 10.1016/0002-9343(74)90003-5. [DOI] [PubMed] [Google Scholar]
  16. Viberti G. C., Hill R. D., Jarrett R. J., Argyropoulos A., Mahmud U., Keen H. Microalbuminuria as a predictor of clinical nephropathy in insulin-dependent diabetes mellitus. Lancet. 1982 Jun 26;1(8287):1430–1432. doi: 10.1016/s0140-6736(82)92450-3. [DOI] [PubMed] [Google Scholar]

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