Skip to main content
NCBI home page
British Medical Journal (Clinical Research Ed.) logoLink to British Medical Journal (Clinical Research Ed.)
. 1988 Jun 4;296(6636):1583–1585. doi: 10.1136/bmj.296.6636.1583

Evaluation of eight and a half years of neonatal screening for haemoglobinopathies in Birmingham

Paul D Griffiths, Jillian R Mann, Philip J Darbyshire, Anne Green
PMCID: PMC2545962  PMID: 3135019

Abstract

A pilot neonatal screening programme for haemoglobinopathies linked with screening for phenylketonuria and congenital hypothyroidism was reviewed. During 1978 to December 1986 137 000 neonates were tested. There were improvements in the detection rate and accuracy of diagnosis for homozygotes and mixed heterozygotes, mainly associated with the introduction of citrate agarose gel electrophoresis as a follow up procedure on all specimens showing any abnormality on the initial cellulose acetate electrophoresis.

We recommend that the programme is continued on a service basis.

Full text

PDF
1583

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Gaston M. H., Verter J. I., Woods G., Pegelow C., Kelleher J., Presbury G., Zarkowsky H., Vichinsky E., Iyer R., Lobel J. S. Prophylaxis with oral penicillin in children with sickle cell anemia. A randomized trial. N Engl J Med. 1986 Jun 19;314(25):1593–1599. doi: 10.1056/NEJM198606193142501. [DOI] [PubMed] [Google Scholar]
  2. Griffiths K. D., Raine D. N., Mann J. R. Neonatal screening for sickle haemoglobinopathies in Birmingham. Br Med J (Clin Res Ed) 1982 Mar 27;284(6320):933–935. doi: 10.1136/bmj.284.6320.933. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Griffiths K. D. Tetramethylbenzidine--a sensitive stain for haemoglobin electrophoresis. Clin Lab Haematol. 1986;8(4):337–340. doi: 10.1111/j.1365-2257.1986.tb00121.x. [DOI] [PubMed] [Google Scholar]
  4. Henthorn J., Anionwu E., Brozovic M. Screening cord blood for sickle haemoglobinopathies in Brent. Br Med J (Clin Res Ed) 1984 Aug 25;289(6443):479–480. doi: 10.1136/bmj.289.6443.479. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Horn M. E., Dick M. C., Frost B., Davis L. R., Bellingham A. J., Stroud C. E., Studd J. W. Neonatal screening for sickle cell diseases in Camberwell: results and recommendations of a two year pilot study. Br Med J (Clin Res Ed) 1986 Mar 15;292(6522):737–740. doi: 10.1136/bmj.292.6522.737. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Jacobs S., Peterson L., Thompson L., Tukey D., Paine-Saunders S., Hedlund B., Smith C., 2nd Newborn screening for hemoglobin abnormalities. A comparison of methods. Am J Clin Pathol. 1986 Jun;85(6):713–715. doi: 10.1093/ajcp/85.6.713. [DOI] [PubMed] [Google Scholar]
  7. Serjeant G. R., Serjeant B. E., Forbes M., Hayes R. J., Higgs D. R., Lehmann H. Haemoglobin gene frequencies in the Jamaican population: a study in 100,000 newborns. Br J Haematol. 1986 Oct;64(2):253–262. doi: 10.1111/j.1365-2141.1986.tb04117.x. [DOI] [PubMed] [Google Scholar]
  8. Whitby L. G. Screening for disease: Definitions and criteria. Lancet. 1974 Oct 5;2(7884):819–822. doi: 10.1016/s0140-6736(74)91082-4. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal (Clinical research ed.) are provided here courtesy of BMJ Publishing Group

RESOURCES