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. 1984 Dec;52(3):833–838. doi: 10.1128/jvi.52.3.833-838.1984

Identification and characterization of a cellular protein that cross-reacts with the Epstein-Barr virus nuclear antigen.

J Luka, T Kreofsky, G R Pearson, K Hennessy, E Kieff
PMCID: PMC254603  PMID: 6208381

Abstract

A 62,000-dalton (62K) cell protein reacts with antisera to the 72K polypeptide of the Epstein-Barr virus nuclear antigen (EBNA) in immunoblots. This protein was initially detected in EBNA-negative as well as EBNA-positive cell lines with anti-EBNA-positive human sera. A monoclonal antibody raised against the 72K EBNA and an antiserum from a rabbit immunized with the glycine-alanine domain of EBNA also reacted with the cellular protein. The cellular protein was partially purified from Epstein-Barr virus genome-positive and -negative cell lines. Absorption experiments identified a shared antigenic determinant between the 72K EBNA and 62K cellular protein. A comparison of the 62K protein and EBNA by protease digestion did not reveal similar peptides.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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