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Journal of Virology logoLink to Journal of Virology
. 1985 Feb;53(2):425–429. doi: 10.1128/jvi.53.2.425-429.1985

Isotype profiles of anti-influenza antibodies in mice bearing the xid defect.

M A Reale, C A Bona, J L Schulman
PMCID: PMC254653  PMID: 3871483

Abstract

The humoral response to influenza A/PR8 virus was examined in the CBA/N and C3J.xid strains of mice, both of which bear an X-linked genetic defect (xid), and in strains lacking this defect. Hemagglutination-inhibiting antibody titers and measurement of virus-specific antibodies by solid-phase radioimmunoassay indicated that the xid defect does not impair the production of an adequate anti-influenza antibody response. However, investigation of the isotypes of PR8 virus-specific antibodies disclosed a relative decrease in the levels of IgG3 and IgG1 in the xid-bearing strains. This was observed after both intraperitoneal immunization and aerosol infection. The isotype differences were not reflected in the susceptibility of these strains to influenza virus infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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