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. 1985 Mar;53(3):984–987. doi: 10.1128/jvi.53.3.984-987.1985

Nucleotide sequence analysis of the BALB/c murine sarcoma virus transforming gene.

E P Reddy, D Lipman, P R Andersen, S R Tronick, S A Aaronson
PMCID: PMC254738  PMID: 2983103

Abstract

We determined the nucleotide sequence of the v-H-ras-related oncogene of BALB/c murine sarcoma virus. This oncogene contains an open reading frame of 189 amino acids that initiates and terminates entirely within the mouse cell-derived ras sequence. The protein encoded by this open reading frame matches the sequence predicted for the T24 human bladder carcinoma oncogene product, p21, in all but two positions. The presence of a lysine residue in position 12 of BALB/c murine sarcoma virus p21 likely accounts for its oncogenic properties.

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Selected References

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