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. 1985 Mar;53(3):994–997. doi: 10.1128/jvi.53.3.994-997.1985

Map location of homologous regions between Marek's disease virus and herpesvirus of turkey and the absence of detectable homology in the putative tumor-inducing gene.

K Fukuchi, M Sudo, A Tanaka, M Nonoyama
PMCID: PMC254741  PMID: 2983105

Abstract

The DNA region having homology between Marek's disease virus and herpesvirus of turkey was assigned to the restriction map of Marek's disease virus by Southern blot hybridization. Under moderate conditions at the level of 15% mismatching, homology was found to be distributed throughout the Marek's disease virus genome. The long inverted-repeat regions (TRL and IRL), which are considered to play a significant role in tumorigenicity, did not show any homology to herpesvirus of turkey DNA.

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Selected References

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  1. Churchill A. E., Payne L. N., Chubb R. C. Immunization against Marek's disease using a live attenuated virus. Nature. 1969 Feb 22;221(5182):744–747. doi: 10.1038/221744a0. [DOI] [PubMed] [Google Scholar]
  2. Fukuchi K., Sudo M., Lee Y. S., Tanaka A., Nonoyama M. Structure of Marek's disease virus DNA: detailed restriction enzyme map. J Virol. 1984 Jul;51(1):102–109. doi: 10.1128/jvi.51.1.102-109.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Gibbs C. P., Nazerian K., Velicer L. F., Kung H. J. Extensive homology exists between Marek disease herpesvirus and its vaccine virus, herpesvirus of turkeys. Proc Natl Acad Sci U S A. 1984 Jun;81(11):3365–3369. doi: 10.1073/pnas.81.11.3365. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hirai K., Honma H., Ikuta K., Kato S. Genetic relatedness of virulent and avirulent strains of Marek's disease virus. Arch Virol. 1984;79(3-4):293–298. doi: 10.1007/BF01310818. [DOI] [PubMed] [Google Scholar]
  5. Hirai K., Ikuta K., Kato S. Comparative studies on Marek's disease virus and herpesvirus of turkey DNAs. J Gen Virol. 1979 Oct;45(1):119–131. doi: 10.1099/0022-1317-45-1-119. [DOI] [PubMed] [Google Scholar]
  6. Hirai K., Ikuta K., Maotani K., Kato S. Evaluation of DNA homology of Marek's disease virus, herpesvirus of turkeys and Epstein-Barr virus under varied stringent hybridization conditions. J Biochem. 1984 Apr;95(4):1215–1218. doi: 10.1093/oxfordjournals.jbchem.a134712. [DOI] [PubMed] [Google Scholar]
  7. Howley P. M., Israel M. A., Law M. F., Martin M. A. A rapid method for detecting and mapping homology between heterologous DNAs. Evaluation of polyomavirus genomes. J Biol Chem. 1979 Jun 10;254(11):4876–4883. [PubMed] [Google Scholar]
  8. Ikuta K., Ueda S., Kato S., Hirai K. Identification with monoclonal antibodies of glycoproteins of Marek's disease virus and herpesvirus of turkeys related to virus neutralization. J Virol. 1984 Mar;49(3):1014–1017. doi: 10.1128/jvi.49.3.1014-1017.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kaschka-Dierich C., Bornkamm G. W., Thomssen R. No homology detectable between Marek's disease virus (MDV) DNA and herpesvirus of the turkey (HVT) DNA. Med Microbiol Immunol. 1979 Jan 24;165(4):223–239. doi: 10.1007/BF02152922. [DOI] [PubMed] [Google Scholar]
  10. Lee L. F., Kieff E. D., Bachenheimer S. L., Roizman B., Spear P. G., Burmester B. R., Nazerian K. Size and composition of Marek's disease virus deoxyribonucleic acid. J Virol. 1971 Mar;7(3):289–294. doi: 10.1128/jvi.7.3.289-294.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Lee Y. S., Tanaka A., Silver S., Smith M., Nonoyama M. Minor DNA homology between herpesvirus of turkey and Marek's disease virus? Virology. 1979 Feb;93(1):277–280. doi: 10.1016/0042-6822(79)90299-x. [DOI] [PubMed] [Google Scholar]
  12. Okazaki W., Purchase H. G., Burmester B. R. Protection against Marek's disease by vaccination with a herpesvirus of turkeys. Avian Dis. 1970 May;14(2):413–429. [PubMed] [Google Scholar]
  13. Rigby P. W., Dieckmann M., Rhodes C., Berg P. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. J Mol Biol. 1977 Jun 15;113(1):237–251. doi: 10.1016/0022-2836(77)90052-3. [DOI] [PubMed] [Google Scholar]
  14. Schat K. A., Calnek B. W. Demonstration of Marek's disease tumor-associated surface antigen in chickens infected with nononcogenic Marek's disease virus and herpesvirus of turkeys. J Natl Cancer Inst. 1978 Sep;61(3):855–857. [PubMed] [Google Scholar]
  15. Schat K. A., Calnek B. W. Protection against Marek's disease-derived tumor transplants by the nononcogenic SB-1 strain of Marek's disease virus. Infect Immun. 1978 Oct;22(1):225–232. doi: 10.1128/iai.22.1.225-232.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Schat K. A., Murthy K. K. In vitro cytotoxicity against Marek's disease lymphoblastoid cell lines after enzymatic removal of Marek's disease tumor-associated surface antigen. J Virol. 1980 Apr;34(1):130–135. doi: 10.1128/jvi.34.1.130-135.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Southern E. M. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol. 1975 Nov 5;98(3):503–517. doi: 10.1016/s0022-2836(75)80083-0. [DOI] [PubMed] [Google Scholar]
  18. Tanaka A., Silver S., Nonoyama M. Biochemical evidence of the nonintegrated status of Marek's disease virus DNA in virus-transformed lymphoblastoid cells of chicken. Virology. 1978 Jul 1;88(1):19–24. doi: 10.1016/0042-6822(78)90105-8. [DOI] [PubMed] [Google Scholar]
  19. Van Zaane D., Brinkhof J. M., Gielkens A. L. Molecular-biological characterization of Marek's disease virus. II. Differentiation of various MDV and HVT strains. Virology. 1982 Aug;121(1):133–146. doi: 10.1016/0042-6822(82)90123-4. [DOI] [PubMed] [Google Scholar]
  20. Van Zaane D., Brinkhof J. M., Westenbrink F., Gielkens A. L. Molecular-biological characterization of Marek's disease virus. I. Identification of virus-specific polypeptides in infected cells. Virology. 1982 Aug;121(1):116–132. doi: 10.1016/0042-6822(82)90122-2. [DOI] [PubMed] [Google Scholar]
  21. Witter R. L., Nazerian K., Purchase H. G., Burgoyne G. H. Isolation from turkeys of a cell-associated herpesvirus antigenically related to Marek's disease virus. Am J Vet Res. 1970 Mar;31(3):525–538. [PubMed] [Google Scholar]

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