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The Journal of Automatic Chemistry logoLink to The Journal of Automatic Chemistry
. 1992;14(5):169–172. doi: 10.1155/S1463924692000312

Automated sampling and analysis in research product synthesis

L Timmermans 1, A Van den Bergh 1, A Verhecken 1, C Van de Sande 1
PMCID: PMC2547975  PMID: 18924948

Abstract

The information obtained about relevant reaction parameters can be greatly increased by monitoring concentration changes during a reaction. To achieve this goal, a fully automated system was designed which handles both sampling and analysis. The sampling system takes samples at predefined intervals, and also performs a number of tasks such as dilution, neutralization, filtration and analysis.

The examples show the universal applicability of the device regarding to solvents, reaction media and reaction type. It is also demonstrated that the information, included in the concentration profiles, greatly increases our knowledge about the reaction. This increase in information, in conjunction with other data,for example calorimetry, could be used for reaction simulation software.

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