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The Journal of Automatic Chemistry logoLink to The Journal of Automatic Chemistry
. 1998;20(1):9–15. doi: 10.1155/S1463924698000029

Effects of experimental design on calibration curve precision in routine analysis

Maria Fernanda Pimentel 1, Benício de Barros Neto 2, Teresa Cristina B Saldanha 3, Mário César Ugulino Araújo 3,
PMCID: PMC2548143  PMID: 18924816

Abstract

A computational program which compares the effciencies of different experimental designs with those of maximum precision (D-optimized designs) is described. The program produces confidence interval plots for a calibration curve and provides information about the number of standard solutions, concentration levels and suitable concentration ranges to achieve an optimum calibration. Some examples of the application of this novel computational program are given, using both simulated and real data.

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