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. 1985 May;54(2):615–618. doi: 10.1128/jvi.54.2.615-618.1985

Effects of pure interferons on Epstein-Barr virus infection in vitro.

J P Andersson, U G Andersson, I T Ernberg, S F Britton, M DeLey
PMCID: PMC254835  PMID: 2580994

Abstract

Pure human gamma-interferon as well as alpha-interferon inhibited induction of immunoglobulin synthesis by Epstein-Barr virus but not by pokeweed mitogen in B lymphocytes from adult but not from newborn humans. The interferons inhibited the infected B lymphocytes directly, irrespective of the Epstein-Barr virus immune status of the donor, and their inhibitory effect was synergistic.

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Selected References

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  1. Adams A., Lidin B., Strander H., Cantell K. Spontaneous interferon production and Epstein-Barr virus antigen expression in human lymphoid cell lines. J Gen Virol. 1975 Aug;28(2):219–223. doi: 10.1099/0022-1317-28-2-219. [DOI] [PubMed] [Google Scholar]
  2. Andersson U., Britton S., De Ley M., Bird G. Evidence for the ontogenic precedence of suppressor T cell functions in the human neonate. Eur J Immunol. 1983 Jan;13(1):6–13. doi: 10.1002/eji.1830130104. [DOI] [PubMed] [Google Scholar]
  3. Andersson U., Martinez-Maza O., Andersson J., Britton S., Gadler H., De Ley M., Modrow S. Secretion of gamma-interferon at the cellular level. Induction by Epstein-Barr virus. Scand J Immunol. 1984 Nov;20(5):425–432. doi: 10.1111/j.1365-3083.1984.tb01021.x. [DOI] [PubMed] [Google Scholar]
  4. Bird A. G., Britton S. A new approach to the study of human B lymphocyte function using an indirect plaque assay and a direct B cell activator. Immunol Rev. 1979;45:41–67. doi: 10.1111/j.1600-065x.1979.tb00272.x. [DOI] [PubMed] [Google Scholar]
  5. Bird A. G., Britton S., Ernberg I., Nilsson K. Characteristics of Epstein-Barr virus activation of human B lymphocytes. J Exp Med. 1981 Sep 1;154(3):832–839. doi: 10.1084/jem.154.3.832. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Branca A. A., Baglioni C. Evidence that types I and II interferons have different receptors. Nature. 1981 Dec 24;294(5843):768–770. doi: 10.1038/294768a0. [DOI] [PubMed] [Google Scholar]
  7. De Ley M., Claeys H. Streptococcal preparation OK-432-induced interferon in human leukocytes: purification and characterization. Int Arch Allergy Appl Immunol. 1984;74(1):21–28. doi: 10.1159/000233510. [DOI] [PubMed] [Google Scholar]
  8. Einhorn L., Ernberg I. Induction of EBNA precedes the first cellular S-phase after EBV-infection of human lymphocytes. Int J Cancer. 1978 Feb 15;21(2):157–160. doi: 10.1002/ijc.2910210205. [DOI] [PubMed] [Google Scholar]
  9. Fleischmann W. R., Jr, Georgiades J. A., Osborne L. C., Johnson H. M. Potentiation of interferon activity by mixed preparations of fibroblast and immune interferon. Infect Immun. 1979 Oct;26(1):248–253. doi: 10.1128/iai.26.1.248-253.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Gray P. W., Leung D. W., Pennica D., Yelverton E., Najarian R., Simonsen C. C., Derynck R., Sherwood P. J., Wallace D. M., Berger S. L. Expression of human immune interferon cDNA in E. coli and monkey cells. Nature. 1982 Feb 11;295(5849):503–508. doi: 10.1038/295503a0. [DOI] [PubMed] [Google Scholar]
  11. Green J. A., Yeh T. J., Overall J. C., Jr Sequential production of IFN-alpha and immune-specific IFN-gamma by human mononuclear leukocytes exposed to herpes simplex virus. J Immunol. 1981 Sep;127(3):1192–1196. [PubMed] [Google Scholar]
  12. Hansson M., Falk K., Ernberg I. Epstein-Barr virus transformation of human pre-B cells. J Exp Med. 1983 Aug 1;158(2):616–622. doi: 10.1084/jem.158.2.616. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hasler F., Bluestein H. G., Zvaifler N. J., Epstein L. B. Analysis of the defects responsible for the impaired regulation of Epstein-Barr virus-induced B cell proliferation by rheumatoid arthritis lymphocytes. I. Diminished gamma interferon production in response to autologous stimulation. J Exp Med. 1983 Jan 1;157(1):173–188. doi: 10.1084/jem.157.1.173. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Henderson E. E., Doetsch P. W., Charubala R., Pfleiderer W., Suhadolnik R. J. Inhibition of Epstein-Barr virus-associated nuclear antigen (EBNA) induction by (2',5')oligoadenylate and the cordycepin analog: mechanism of action for inhibition of EBV-induced transformation. Virology. 1982 Oct 15;122(1):198–201. doi: 10.1016/0042-6822(82)90389-0. [DOI] [PubMed] [Google Scholar]
  15. Keightley R. G., Cooper M. D., Lawton A. R. The T cell dependence of B cell differentiation induced by pokeweed mitogen. J Immunol. 1976 Nov;117(5 Pt 1):1538–1544. [PubMed] [Google Scholar]
  16. Lvovsky E., Levine P. H., Fuccillo D., Ablashi D. V., Bengali Z. H., Armstrong G. R., Levy H. B. Epstein-Barr virus and Herpesvirus saimiri: sensitivity to interferons and interferon inducers. J Natl Cancer Inst. 1981 Jun;66(6):1013–1019. doi: 10.1093/jnci/66.6.1013. [DOI] [PubMed] [Google Scholar]
  17. Martinez-Maza O., Andersson U., Andersson J., Britton S., De Ley M. Spontaneous production of interferon-gamma in adult and newborn humans. J Immunol. 1984 Jan;132(1):251–255. [PubMed] [Google Scholar]
  18. Menezes J., Patel P., Dussault H., Joncas J., Leibold W. Effect of interferon on lymphocyte transformation and nuclear antigen production by Epstein-Barr virus. Nature. 1976 Apr 1;260(5550):430–432. doi: 10.1038/260430a0. [DOI] [PubMed] [Google Scholar]
  19. Miller G., Lipman M. Comparison of the yield of infectious virus from clones of human and simian lymphoblastoid lines transformed by Epstein-Barr virus. J Exp Med. 1973 Dec 1;138(6):1398–1412. doi: 10.1084/jem.138.6.1398. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Nakayama T. Immune-specific production of gamma interferon in human lymphocyte cultures in response to mumps virus. Infect Immun. 1983 May;40(2):486–492. doi: 10.1128/iai.40.2.486-492.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Reedman B. M., Klein G. Cellular localization of an Epstein-Barr virus (EBV)-associated complement-fixing antigen in producer and non-producer lymphoblastoid cell lines. Int J Cancer. 1973 May;11(3):499–520. doi: 10.1002/ijc.2910110302. [DOI] [PubMed] [Google Scholar]
  22. Secher D. S., Burke D. C. A monoclonal antibody for large-scale purification of human leukocyte interferon. Nature. 1980 Jun 12;285(5765):446–450. doi: 10.1038/285446a0. [DOI] [PubMed] [Google Scholar]
  23. Slovin S. F., Schooley R. T., Thorley-Lawson D. A. Analysis of cellular immune response to EBV by using cloned T cell lines. J Immunol. 1983 May;130(5):2127–2132. [PubMed] [Google Scholar]
  24. Starr S. E., Dalton B., Garrabrant T., Paucker K., Plotkin S. A. Lymphocyte blastogenesis and interferon production in adult human leukocyte cultures stimulated with cytomegalovirus antigens. Infect Immun. 1980 Oct;30(1):17–22. doi: 10.1128/iai.30.1.17-22.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Thorley-Lawson D. A. The transformation of adult but not newborn human lymphocytes by Epstein Barr virus and phytohemagglutinin is inhibited by interferon: the early suppression by T cells of Epstein Barr infection is mediated by interferon. J Immunol. 1981 Mar;126(3):829–833. [PubMed] [Google Scholar]
  26. Wiranowska-Stewart M., Stewart W. E., 2nd Determination of human leukocyte populations involved in production of interferons alpha and gamma. J Interferon Res. 1981 Feb;1(2):233–244. doi: 10.1089/jir.1981.1.233. [DOI] [PubMed] [Google Scholar]
  27. Yefenof E., Bakacs T., Einhorn L., Ernberg I., Klein G. Epstein-Barr virus (EBV) receptors, complement receptors, and EBV infectibility of different lymphocyte fractions of human peripheral blood. I. Complement receptor distribution and complement binding by separated lymphocyte subpopulations. Cell Immunol. 1978 Jan;35(1):34–42. doi: 10.1016/0008-8749(78)90124-7. [DOI] [PubMed] [Google Scholar]

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