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. 1985 Jul;55(1):173–176. doi: 10.1128/jvi.55.1.173-176.1985

Chemotherapy and vaccination: a possible strategy for the control of highly virulent influenza virus.

R G Webster, Y Kawaoka, W J Bean, C W Beard, M Brugh
PMCID: PMC254912  PMID: 4009792

Abstract

The influenza A virus [A/Chicken/Pennsylvania/1370/83 (H5N2)] that caused up to 80% mortality among chickens provided a model system for testing the efficacy of chemotherapeutic agents against highly virulent influenza virus. Amantadine and rimantadine administered in drinking water were efficacious both prophylactically and therapeutically. However, under conditions simulating natural transmission of virus, amantadine- and rimantadine-resistant viruses arose and were transmitted to other birds in contact with the infected chickens, causing mortality. Simultaneous administration of inactivated H5N2 vaccine and amantadine provided protection. Thus, chemotherapy may be useful in the treatment of a highly pathogenic influenza virus outbreak in humans or other animals when used in combination with vaccine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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