Skip to main content
NCBI home page
Journal of Virology logoLink to Journal of Virology
. 1985 Jan;53(1):75–80. doi: 10.1128/jvi.53.1.75-80.1985

Effect of immunosuppression on experimental Argentine hemorrhagic fever in guinea pigs.

R H Kenyon, D E Green, C J Peters
PMCID: PMC254980  PMID: 2981364

Abstract

Immunosuppression with cyclosporin A or cyclophosphamide had no apparent effect on the disease course of guinea pigs infected with a virulent strain of Junin virus. Immunosuppression of guinea pigs infected with an attenuated strain of Junin virus led to fulminating Argentine hemorrhagic fever. All immunosuppressed infected animals died. Virus distribution patterns in target organs, as determined by plaque assay and fluorescent antibody procedures, were similar to those from non-immunosuppressed animals infected with a virulent strain. Histopathological lesions in immunosuppressed guinea pigs infected with an attenuated strain of virus were similar to those in non-immunosuppressed guinea pigs infected with a virulent strain. Histological changes attributable to the immunosuppressive drug(s) were regularly observed. Immunosuppressed animals infected with attenuated Junin virus and non-immunosuppressed animals infected with virulent virus failed to develop antibody or responded at a minimal level. Virus-specific cytotoxic spleen cell activity, previously shown to be antibody dependent, failed to develop in the same animals. The presence of a competent immune response, probably serum antibody, determined whether Argentine hemorrhagic fever infection of the guinea pig was lethal or whether recovery ensued; no evidence for harmful effects of the immune response was obtained.

Full text

PDF
75

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Borel J. F., Feurer C., Magnée C., Stähelin H. Effects of the new anti-lymphocytic peptide cyclosporin A in animals. Immunology. 1977 Jun;32(6):1017–1025. [PMC free article] [PubMed] [Google Scholar]
  2. Bro-Jorgensen K., Volkert M. Haemopoietic defects in mice infected with lymphocytic choriomeningitis virus. 1. The enhanced x-ray sensitivity of virus infected mice. Acta Pathol Microbiol Scand B Microbiol Immunol. 1972;80(6):845–852. doi: 10.1111/j.0365-5563.1973.tb00010.x. [DOI] [PubMed] [Google Scholar]
  3. Carballal G., Cossio P. M., Laguens R. P., Ponzinibbio C., Oubiña J. R., Meckert P. C., Rabinovich A., Arana R. M. Junin virus infection of guinea pigs: immunohistochemical and ultrastructural studies of hemopoietic tissue. J Infect Dis. 1981 Jan;143(1):7–14. doi: 10.1093/infdis/143.1.7. [DOI] [PubMed] [Google Scholar]
  4. Elsner B., Boxaca M. C., Weissenbacher M., De Guerrero L. B. Estudio de la infección experimental del cobayo con virus Junin. I. Anatomía patológica. Medicina (B Aires) 1976 May-Jun;36(3):197–206. [PubMed] [Google Scholar]
  5. Galassi N. V., Blejer J. L., Barrios H., Nejamkis M. R., Nota N. R. New attenuation marker for junin virus based on immunologic responses of guinea pigs. J Infect Dis. 1982 Mar;145(3):331–336. doi: 10.1093/infdis/145.3.331. [DOI] [PubMed] [Google Scholar]
  6. Giovanniello O. A., Nejamkis M. R., Galassi N. V., Nota N. R. Immunosuppression in experimental Junin virus infection of mice. Intervirology. 1980;13(2):122–125. doi: 10.1159/000149116. [DOI] [PubMed] [Google Scholar]
  7. Introna M., Allavena P., Spreafico F., Mantovani A. Inhibition of human natural killer activity by cyclosporin A. Transplantation. 1981 Feb;31(2):113–116. doi: 10.1097/00007890-198102000-00004. [DOI] [PubMed] [Google Scholar]
  8. Jahrling P. B., Hesse R. A., Rhoderick J. B., Elwell M. A., Moe J. B. Pathogenesis of a pichinde virus strain adapted to produce lethal infections in guinea pigs. Infect Immun. 1981 May;32(2):872–880. doi: 10.1128/iai.32.2.872-880.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Jahrling P. B., Smith S., Hesse R. A., Rhoderick J. B. Pathogenesis of Lassa virus infection in guinea pigs. Infect Immun. 1982 Aug;37(2):771–778. doi: 10.1128/iai.37.2.771-778.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Johnson E. D., Monjan A. A., Morse H. C., 3rd Lack of B-cell participation in acute lymphocyte choriomeningitis disease of the central nervous system. Cell Immunol. 1978 Mar 1;36(1):143–150. doi: 10.1016/0008-8749(78)90257-5. [DOI] [PubMed] [Google Scholar]
  11. Maiztegui J. I., Fernandez N. J., de Damilano A. J. Efficacy of immune plasma in treatment of Argentine haemorrhagic fever and association between treatment and a late neurological syndrome. Lancet. 1979 Dec 8;2(8154):1216–1217. doi: 10.1016/s0140-6736(79)92335-3. [DOI] [PubMed] [Google Scholar]
  12. Mims C. A., Tosolini F. A. Pathogenesis of lesions in lymphoid tissue of mice infected with lymphocytic choriomeningitis (LCM) virus. Br J Exp Pathol. 1969 Dec;50(6):584–592. [PMC free article] [PubMed] [Google Scholar]
  13. Paavonen T., Häyry P. Effect of cyclosporin A on T-dependent and T-independent immunoglobulin synthesis in vitro. Nature. 1980 Oct 9;287(5782):542–544. doi: 10.1038/287542a0. [DOI] [PubMed] [Google Scholar]
  14. Parodi A. S., Schmunis G. A., Weissenbacher M. C. Infection with viruses of the Tacaribe group in thymectomized mice. Experientia. 1970 Jun 15;26(6):665–666. doi: 10.1007/BF01898754. [DOI] [PubMed] [Google Scholar]
  15. Peters C. J., Webb P. A., Johnson K. M. Measurement of antibodies to Machupo virus by the indirect fluorescent technique. Proc Soc Exp Biol Med. 1973 Feb;142(2):526–531. doi: 10.3181/00379727-142-37060. [DOI] [PubMed] [Google Scholar]
  16. Silberman S. L., Jacobs R. P., Cole G. A. Mechanisms of hemopoietic and immunological dysfunction induced by lymphocytic choriomeningitis virus. Infect Immun. 1978 Feb;19(2):533–539. doi: 10.1128/iai.19.2.533-539.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Stockman G. D., Heim L. R., South M. A., Trentin J. J. Differential effects of cyclophosphamide on the B and T cell compartments of adult mice. J Immunol. 1973 Jan;110(1):277–282. [PubMed] [Google Scholar]
  18. Thomson A. W. Immunobiology of cyclosporin A--a review. Aust J Exp Biol Med Sci. 1983 Apr;61(Pt 2):147–172. doi: 10.1038/icb.1983.14. [DOI] [PubMed] [Google Scholar]
  19. Turk J. L., Parker D. Further studies on B-lymphocyte suppression in delayed hypersensitivity, indicating a possible mechanism for Jones-Mote hypersensitivity. Immunology. 1973 Apr;24(4):751–758. [PMC free article] [PubMed] [Google Scholar]
  20. Webb P. A., Johnson K. M., Mackenzie R. B. The measurement of specific antibodies in Bolivian hemorrhagic fever by neutralization of virus plaques. Proc Soc Exp Biol Med. 1969 Mar;130(3):1013–1019. doi: 10.3181/00379727-130-33711. [DOI] [PubMed] [Google Scholar]
  21. Weissenbacher M. C., Laguens R. P., Quintans C. J., Calello M. A., Montoro L., Woyskowsky N. M., Zannoli V. H. Persistencia viral y ausencia de lesiones en el encéfalo de ratones congénitamente atímicos infectados con virus Junin. Medicina (B Aires) 1983;43(4):403–409. [PubMed] [Google Scholar]
  22. Weissenbacher M. C., de Guerrero L. B., Boxaca M. C. Experimental biology and pathogenesis of Junin virus infection in animals and man. Bull World Health Organ. 1975;52(4-6):507–515. [PMC free article] [PubMed] [Google Scholar]
  23. Weissenbacher M., De Guerrero L. B., Parodi A. S. Acción de los inmunosueros en la fiebre hemorrágica experimental. Medicina (B Aires) 1968 Mar-Apr;28(2):53–58. [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES