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. 1985 Jan;53(1):89–93. doi: 10.1128/jvi.53.1.89-93.1985

Presence of markers for virulence in the unique short region or repeat region or both of pseudorabies hybrid viruses.

A Berns, A van den Ouweland, W Quint, J van Oirschot, A Gielkens
PMCID: PMC254982  PMID: 2981366

Abstract

The unique short region and part of the repeat region of virulent pseudorabies virus strain NIA-3 was replaced by the corresponding region of the avirulent NIA-4 strain by transfection with subgenomic DNA fragments. The resulting hybrid virus showed a reduced virulence in both mice and pigs. Therefore, important markers for virulence are located in the unique short or repeat region or both of pseudorabies virus. We provide evidence that the terminally located repeat is not required for the generation of progeny with intact pseudorabies virus genomes. Apparently, the terminal repeat is regenerated from the internal repeat.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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