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. 1985 Sep;55(3):831–835. doi: 10.1128/jvi.55.3.831-835.1985

trans-Activation of the human T-cell leukemia virus long terminal repeat correlates with expression of the x-lor protein.

J G Sodroski, W C Goh, C A Rosen, S Z Salahuddin, A Aldovini, G Franchini, F Wong-Staal, R C Gallo, K Sugamura, Y Hinuma, et al.
PMCID: PMC255069  PMID: 2991599

Abstract

Cell lines established directly from adult T-cell leukemia-lymphoma patients or immortalized by human T-cell leukemia virus type I (HTLV-I) in vitro that do not produce complete HTLV virions were characterized both for the content of viral proteins and for the presence of trans-acting factors activating gene expression under the control of the HTLV long terminal repeat. The expression of the 42-kilodalton HTLV x-lor product correlated with trans-activation of the long terminal repeat. The implications of this study for understanding the role of the HTLV x-lor product in the initiation and maintenance of T-lymphocyte transformation are discussed.

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Selected References

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