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. 1985 Sep;55(3):867–869. doi: 10.1128/jvi.55.3.867-869.1985

Enhancement of the transforming capacity of BK virus by partial deletion of the 68-base-pair tandem repeats.

K Hara, Y Oya, Y Yogo
PMCID: PMC255077  PMID: 2991606

Abstract

We constructed a set of deleted BK viral DNAs that lack part of the triplicated 68-base-pair (bp) sequences (the central unit has an 18-bp deletion) and assayed them for capacity to transform hamster kidney cells. Deletion of one of the two 68-bp units remarkably enhanced transforming capacity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Gardner S. D., Field A. M., Coleman D. V., Hulme B. New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet. 1971 Jun 19;1(7712):1253–1257. doi: 10.1016/s0140-6736(71)91776-4. [DOI] [PubMed] [Google Scholar]
  2. Graham F. L., van der Eb A. J. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology. 1973 Apr;52(2):456–467. doi: 10.1016/0042-6822(73)90341-3. [DOI] [PubMed] [Google Scholar]
  3. Peden K. W. Revised sequence of the tetracycline-resistance gene of pBR322. Gene. 1983 May-Jun;22(2-3):277–280. doi: 10.1016/0378-1119(83)90112-9. [DOI] [PubMed] [Google Scholar]
  4. Rosenthal N., Kress M., Gruss P., Khoury G. BK viral enhancer element and a human cellular homolog. Science. 1983 Nov 18;222(4625):749–755. doi: 10.1126/science.6314501. [DOI] [PubMed] [Google Scholar]
  5. Seif I., Khoury G., Dhar R. The genome of human papovavirus BKV. Cell. 1979 Dec;18(4):963–977. doi: 10.1016/0092-8674(79)90209-5. [DOI] [PubMed] [Google Scholar]
  6. Sutcliffe J. G. Complete nucleotide sequence of the Escherichia coli plasmid pBR322. Cold Spring Harb Symp Quant Biol. 1979;43(Pt 1):77–90. doi: 10.1101/sqb.1979.043.01.013. [DOI] [PubMed] [Google Scholar]
  7. Takemoto K. K., Martin M. A. Transformation of hamster kidney cells by BK papovavirus DNA. J Virol. 1975 Jan;17(1):247–253. doi: 10.1128/jvi.17.1.247-253.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Watanabe S., Soeda E., Uchida S., Yoshiike K. DNA rearrangement affecting expression of the BK virus transforming gene. J Virol. 1984 Jul;51(1):1–6. doi: 10.1128/jvi.51.1.1-6.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Watanabe S., Yogo Y., Yoshiike K. Expression of viral early functions in rat 3Y1 cells infected with human papovavirus BK. J Virol. 1984 Jan;49(1):78–85. doi: 10.1128/jvi.49.1.78-85.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Watanabe S., Yoshiike K. Change of DNA near the origin of replication enhances the transforming capacity of human papovavirus BK. J Virol. 1982 Jun;42(3):978–985. doi: 10.1128/jvi.42.3.978-985.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Watanabe S., Yoshiike K., Nozawa A., Yuasa Y., Uchida S. Viable deletion mutant of human papovavirus BK that induces insulinomas in hamsters. J Virol. 1979 Dec;32(3):934–942. doi: 10.1128/jvi.32.3.934-942.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Yang R. C., Wu R. BK virus DNA: complete nucleotide sequence of a human tumor virus. Science. 1979 Oct 26;206(4417):456–462. doi: 10.1126/science.228391. [DOI] [PubMed] [Google Scholar]
  13. de Villiers J., Schaffner W., Tyndall C., Lupton S., Kamen R. Polyoma virus DNA replication requires an enhancer. Nature. 1984 Nov 15;312(5991):242–246. doi: 10.1038/312242a0. [DOI] [PubMed] [Google Scholar]

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