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. 1983 Apr;46(1):131–136. doi: 10.1128/jvi.46.1.131-136.1983

Human Adenovirus Type 2 but Not Adenovirus Type 12 Is Mutagenic at the Hypoxanthine Phosphoribosyltransferase Locus of Cloned Rat Liver Epithelial Cells

Christos Paraskeva 1,†, Carl Roberts 1, Paul Biggs 1, Phillip H Gallimore 1
PMCID: PMC255100  PMID: 6572280

Abstract

Using resistance to the base analog 8-azaguanine as a genetic marker, we showed that adenovirus type 2, but not adenovirus type 12, is mutagenic at the hypoxanthine phosphoribosyltransferase locus of cloned diploid rat liver epithelial cells. Adenovirus type 2 increased the frequency of 8-azaguanine-resistant colonies by up to ninefold over the spontaneous frequency, depending on expression time and virus dose.

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Selected References

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