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Journal of Virology logoLink to Journal of Virology
. 1983 May;46(2):557–566. doi: 10.1128/jvi.46.2.557-566.1983

Comparative analysis of the human type 1a and bovine type 1 papillomavirus genomes.

O Danos, L W Engel, E Y Chen, M Yaniv, P M Howley
PMCID: PMC255158  PMID: 6302319

Abstract

The DNA sequences of the genomes of the bovine type 1 and human type 1a papillomaviruses were compared. The overall organization of both genomes is very similar. Three areas of maximal homology were found in the L1 and E1/E2 genes, and at the beginning of L2. The conservation of homologous amino acid sequences encoded in the open reading frames argues that these segments represent real genes or exons. Within these segments, however, only certain domains of the putative proteins are preferentially conserved. Two polypeptide chains show homologous arrangement of the cysteine residue clusters Cys-X-X-Cys, despite a lack of conservation of the rest of the amino acid sequence. A significant sequence divergence in a region where the three reading frames are open suggests that papillomavirus genomes have evolved not solely by accumulation of point mutations. Conserved sequences were also found in the noncoding region, and their possible involvement in regulation of viral gene expression is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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