TABLE 1.

Pancreas transcripts downregulated in Ngn3^−/− mice

Gene ontology term (biological process)	E12.5 threefold down	E15.5 threefold down	E18.5 threefold down
Regulation of cellular process	Atrx, Sfpq, Braf, Nrip1, Zfp458, Rest, Klf7, Neurod1, Zfp398, Cpsf6, Nfia, Zfp192, Ncoa7, Crim1, Meis1, Mbtps1, Hnrpab, Hdac2, Zfp207, Gas2l3, Fubp1, Onecut2, Ercc6, Rbm5, Rapgef5, Arid5b, D030022P06Rik, Gna13, Shprh, Scmh1, Foxp2, and Paip1	Pax6, Neurod1, Fev, St18, Neurog3, Isl1, and Ins2	Pitx2, Fgd4, Nr3c2, Rapgef1, Rcor2, Il2, Gtf2i, Zfpm2, Stk36, Jarid1d, Inpp5d, Elavl1, E130112L23Rik, Rasgrf1, Zfp580, Zw10, Dnmt3a, Igfbp1, Cideb, Pax6, Rora, Spock2, Gtf3c1, Mlxipl, Nr2f2, Ins2, Tcfec, Malt1, Hcfc1, Neurod1, Igsf1, Itsn1, Ikzf1, Grm2, Isl1, Apoa2, Cables1, Mapk8ip2, Smurf1, Hipk1, Rps6ka5, Sim1, A230083H22Rik, Psd, Gli3, Nf1, Khdrbs3, Klf9, Braf, Pknox2, Tgfbr1, Gata1, Etv1, Smarca2, Bcl2l2, Ahsg, Dlg5, Ptpn11, Eda, Iqgap1, Pde6h, Brdt, Adam10, C030010B13Rik, Gatad2b, Mmp9, Ccnc, Cacna1a, Mecp2, Pde6g, Zdhhc17, Mafb, Ighmbp2, Creb1, Cdc37l1, Edg2, Pdlim1, Lst1, Calcoco1, Nkx6-1, AI324046, BC031441, Rph3al, Pias1, Tcf7l2, Sox13, St18, Frzb, Sebox, Ciapin1, Eef1a2, Rbx1, Batf, Fgf9, Ccna1, Dhcr24, Nono, Foxn4, and Hoxd3
Transport	Abcb10, Huwe1, Colec10, Mbtps1, Atp8a1, Gcg, Napg, Exoc5, and Kif23	Gcg, Ghrl, Cadps, Syt13, Slc7a14, Ins1, Ins2, and Sytl4	Kif3b, Fabp1, Col4a6, Atp6v0a1, Kcnn2, Atp2a3, Fndc5, Atp11c, Syt13, Ins1, Zw10, Atp6v1g2, Snap25, Ghrl, Timm22, Atp1b1, Slc4a1, Uqcrq, Scn4a, Cadps, Lrp11, Fars2, Slc30a8, Laptm5, Aplp1, Ins2, Snx26, Slc2a5, Itpr2, Malt1, Sv2b, Slc9a1, Sytl4, Itsn1, Grm2, Apoa2, Slco2b1, Slc16a9, Rab23, Rab21, Rab37, Camk2b, Anxa6, Slc16a10, Ahsg, Stxbp1, Uty, Ptpn11, Eda, Apoa1, Brdt, Slc7a14, Adam10, 1300017J02Rik, Col11a2, Ap3m2, Lin7b, Cacna1a, Gcg, Zdhhc17, Prkcb1, Kif13a, AI324046, Thoc4, Abcc8, Rph3al, Igf2r, Mon1b, Ap4b1, Afp, Slc35a5, Syt7, Trpm5, Scnn1b, Fgf9, Slc39a2, Foxn4, and Scg5
System development	Atrx, Mtss1, Nrip1, Neurod1, Cxadr, Ppp3cb, Mbp, Rapgef5, and Gna13	Pax6, Neurod1, Neurog3, Isl1, and Insm1	Pitx2, Casq2, Pip5k1c, Rapgef1, Il2, Atp6v0a1, Inpp5d, Crybb1, Crybb3, Pax6, Spock2, Chrdl1, Nr2f2, Aplp1, Tnfaip2, Neurod1, Ikzf1, Isl1, Apoa2, Robo1, Cables1, Smurf1, Sim1, Rab23, Papss2, Gli3, Nf1, Hsd11b1, Scube1, Tgfbr1, Add2, Etv1, Arts1, Ahsg, Stxbp1, Ptpn11, Eda, Apoa1, Tmprss6, Mmp9, Mecp2, Tnfrsf11a, Ankrd17, Mafb, Creb1, Lst1, Ptprj, Nkx6-1, Epm2a, Mepe, Insm1, Afp, Ciapin1, Efnb2, Fgf9, Dhcr24, Lor, Slitrk6, Foxn4, and Hoxd3
Cellular biosynthetic process	Gch1, St8sia3, Galnt7, Etnk1, Zdhhc2, and Paip1	Gch1	Gch1, Inpp5d, Fut10, Atp6v1g2, Fars2, Apoa2, Pank2, Zdhhc2, St8sia5, Mecr, Pigx, Zdhhc17, Dct, Nmt2, Dio2, Eif2s3, Eef1a2, Cps1, Umps, and Foxn4
Cell cycle process	Bub3, Gas2l3, and Rbm5	0	Zw10, Hcfc1, Cables1, A230083H22Rik, Camk2b, Ptpn11, Ccnc, Cdc37l1, Suv39h2, Rbx1, Fgf9, and Ccna1
Cellular component organization and biogenesis	Mtss1, Bub3, Cbx5, Cxadr, Huwe1, Crim1, Mbtps1, Hdac2, Setd8, Pot1a, Napg, Gna13, Shprh, and Kif23	Pax6, Cadps, 4930488E11Rik, and Sytl4	Kif3b, Fgd4, Pip5k1c, Fndc5, Ush1c, Fmn2, Zw10, Dnmt3a, Igfbp1, Pax6, Rtel1, Timm22, Cadps, Lrp11, Aplp1, Malt1, Sytl4, Itsn1, Robo1, Rps6ka5, Fhod1, Etv1, Smarca2, Ahsg, Stxbp1, Ptpn11, Eda, Brdt, Adam10, 6330505N24Rik, Ap3m2, Tmsb10, Mecp2, Hist3h2a, Creb1, Lst1, Kif13a, AI324046, Thoc4, 4930488E11Rik, Rph3al, Ap4b1, Suv39h2, Hist3h2ba, Syt7, Fgf9, Dhcr24, Slitrk6, and Scg5

Data are stratified by developmental age and gene ontology (biological process) as defined by FatiGO (http://fatigo.bioinfo.cipf.es). Further information on each gene (http://www.ensembl.org/Mus_musculus/geneview) is accessible by clicking on the common gene name.