Skip to main content
PMC home page
Journal of Virology logoLink to Journal of Virology
. 1983 May;46(2):653–655. doi: 10.1128/jvi.46.2.653-655.1983

Inhibition of a common human anti-hepatitis B surface antigen idiotype by a cyclic synthetic peptide.

R C Kennedy, G R Dreesman, J T Sparrow, A R Culwell, Y Sanchez, I Ionescu-Matiu, F B Hollinger, J L Melnick
PMCID: PMC255172  PMID: 6188865

Abstract

A common human anti-hepatitis B surface antigen idiotype-anti-idiotype reaction was partially inhibited by a cyclic synthetic hepatitis B surface antigen peptide. Reduction of the intrachain disulfide bond and subsequent alkylation destroyed its inhibitory activity, suggesting that a conformation-dependent group alpha epitope was associated with this cyclic peptide.

Full text

PDF
653

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atassi M. Z. Antigenic structure of myoglobin: the complete immunochemical anatomy of a protein and conclusions relating to antigenic structures of proteins. Immunochemistry. 1975 May;12(5):423–438. doi: 10.1016/0019-2791(75)90010-5. [DOI] [PubMed] [Google Scholar]
  2. Bhatnagar P. K., Papas E., Blum H. E., Milich D. R., Nitecki D., Karels M. J., Vyas G. N. Immune response to synthetic peptide analogues of hepatitis B surface antigen specific for the a determinant. Proc Natl Acad Sci U S A. 1982 Jul;79(14):4400–4404. doi: 10.1073/pnas.79.14.4400. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dreesman G. R., Hollinger F. B., McCombs R. M., Melnick J. L. Alteration of hepatitis B antigen (HB Ag) determinants by reduction and alkylation. J Gen Virol. 1973 Apr;19(1):129–134. doi: 10.1099/0022-1317-19-1-129. [DOI] [PubMed] [Google Scholar]
  4. Dreesman G. R., Hollinger F. B., Sanchez Y., Oefinger P., Melnick J. L. Immunization of chimpanzees with hepatitis B virus-derived polypeptides. Infect Immun. 1981 Apr;32(1):62–67. doi: 10.1128/iai.32.1.62-67.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dreesman G. R., Sanchez Y., Ionescu-Matiu I., Sparrow J. T., Six H. R., Peterson D. L., Hollinger F. B., Melnick J. L. Antibody to hepatitis B surface antigen after a single inoculation of uncoupled synthetic HBsAg peptides. Nature. 1982 Jan 14;295(5845):158–160. doi: 10.1038/295158a0. [DOI] [PubMed] [Google Scholar]
  6. Kennedy R. C., Dreesman G. R. Common idiotypic determinant associated with human antibodies to hepatitis B surface antigen. J Immunol. 1983 Jan;130(1):385–389. [PubMed] [Google Scholar]
  7. Lerner R. A., Green N., Alexander H., Liu F. T., Sutcliffe J. G., Shinnick T. M. Chemically synthesized peptides predicted from the nucleotide sequence of the hepatitis B virus genome elicit antibodies reactive with the native envelope protein of Dane particles. Proc Natl Acad Sci U S A. 1981 Jun;78(6):3403–3407. doi: 10.1073/pnas.78.6.3403. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. McAuliffe V. J., Purcell R. H., Gerin J. L. Type B hepatitis: a review of current prospects for a safe and effective vaccine. Rev Infect Dis. 1980 May-Jun;2(3):470–492. doi: 10.1093/clinids/2.3.470. [DOI] [PubMed] [Google Scholar]
  9. Melnick J. L., Dreesman G. R., Hollinger F. B. Approaching the control of viral hepatitis type B. J Infect Dis. 1976 Feb;133(2):210–229. doi: 10.1093/infdis/133.2.210. [DOI] [PubMed] [Google Scholar]
  10. Moriarty A. M., Hoyer B. H., Shih J. W., Gerin J. L., Hamer D. H. Expression of the hepatitis B virus surface antigen gene in cell culture by using a simian virus 40 vector. Proc Natl Acad Sci U S A. 1981 Apr;78(4):2606–2610. doi: 10.1073/pnas.78.4.2606. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Peterson D. L. Isolation and characterization of the major protein and glycoprotein of hepatitis B surface antigen. J Biol Chem. 1981 Jul 10;256(13):6975–6983. [PubMed] [Google Scholar]
  12. Prince A. M., Ikram H., Hopp T. P. Hepatitis B virus vaccine: identification of HBsAg/a and HBsAg/d but not HBsAg/y subtype antigenic determinants on a synthetic immunogenic peptide. Proc Natl Acad Sci U S A. 1982 Jan;79(2):579–582. doi: 10.1073/pnas.79.2.579. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Sanchez Y., Ionescu-Matiu I. I., Sparrow J. T., Melnick J. L., Dreesman G. R. Immunogenicity of conjugates and micelles of synthetic hepatitis B surface antigen peptides. Intervirology. 1982;18(4):209–213. doi: 10.1159/000149327. [DOI] [PubMed] [Google Scholar]
  14. Sukeno N., Shirachi R., Yamaguchi J., Ishida N. Reduction and reoxidation of Australia antigen: loss and reconstitution of particle structure and antigenicity. J Virol. 1972 Jan;9(1):182–183. doi: 10.1128/jvi.9.1.182-183.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Tiollais P., Charnay P., Vyas G. N. Biology of hepatitis B virus. Science. 1981 Jul 24;213(4506):406–411. doi: 10.1126/science.6264599. [DOI] [PubMed] [Google Scholar]
  16. Vyas G. N., Rao K. R., Ibrahim A. B. Australia antigen (hepatitis B antigen): a conformational antigen dependent on disulfide bonds. Science. 1972 Dec 22;178(4067):1300–1301. doi: 10.1126/science.178.4067.1300. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES