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. 1983 May;46(2):653–655. doi: 10.1128/jvi.46.2.653-655.1983

Inhibition of a common human anti-hepatitis B surface antigen idiotype by a cyclic synthetic peptide.

R C Kennedy, G R Dreesman, J T Sparrow, A R Culwell, Y Sanchez, I Ionescu-Matiu, F B Hollinger, J L Melnick
PMCID: PMC255172  PMID: 6188865

Abstract

A common human anti-hepatitis B surface antigen idiotype-anti-idiotype reaction was partially inhibited by a cyclic synthetic hepatitis B surface antigen peptide. Reduction of the intrachain disulfide bond and subsequent alkylation destroyed its inhibitory activity, suggesting that a conformation-dependent group alpha epitope was associated with this cyclic peptide.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atassi M. Z. Antigenic structure of myoglobin: the complete immunochemical anatomy of a protein and conclusions relating to antigenic structures of proteins. Immunochemistry. 1975 May;12(5):423–438. doi: 10.1016/0019-2791(75)90010-5. [DOI] [PubMed] [Google Scholar]
  2. Bhatnagar P. K., Papas E., Blum H. E., Milich D. R., Nitecki D., Karels M. J., Vyas G. N. Immune response to synthetic peptide analogues of hepatitis B surface antigen specific for the a determinant. Proc Natl Acad Sci U S A. 1982 Jul;79(14):4400–4404. doi: 10.1073/pnas.79.14.4400. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dreesman G. R., Hollinger F. B., McCombs R. M., Melnick J. L. Alteration of hepatitis B antigen (HB Ag) determinants by reduction and alkylation. J Gen Virol. 1973 Apr;19(1):129–134. doi: 10.1099/0022-1317-19-1-129. [DOI] [PubMed] [Google Scholar]
  4. Dreesman G. R., Hollinger F. B., Sanchez Y., Oefinger P., Melnick J. L. Immunization of chimpanzees with hepatitis B virus-derived polypeptides. Infect Immun. 1981 Apr;32(1):62–67. doi: 10.1128/iai.32.1.62-67.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dreesman G. R., Sanchez Y., Ionescu-Matiu I., Sparrow J. T., Six H. R., Peterson D. L., Hollinger F. B., Melnick J. L. Antibody to hepatitis B surface antigen after a single inoculation of uncoupled synthetic HBsAg peptides. Nature. 1982 Jan 14;295(5845):158–160. doi: 10.1038/295158a0. [DOI] [PubMed] [Google Scholar]
  6. Kennedy R. C., Dreesman G. R. Common idiotypic determinant associated with human antibodies to hepatitis B surface antigen. J Immunol. 1983 Jan;130(1):385–389. [PubMed] [Google Scholar]
  7. Lerner R. A., Green N., Alexander H., Liu F. T., Sutcliffe J. G., Shinnick T. M. Chemically synthesized peptides predicted from the nucleotide sequence of the hepatitis B virus genome elicit antibodies reactive with the native envelope protein of Dane particles. Proc Natl Acad Sci U S A. 1981 Jun;78(6):3403–3407. doi: 10.1073/pnas.78.6.3403. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. McAuliffe V. J., Purcell R. H., Gerin J. L. Type B hepatitis: a review of current prospects for a safe and effective vaccine. Rev Infect Dis. 1980 May-Jun;2(3):470–492. doi: 10.1093/clinids/2.3.470. [DOI] [PubMed] [Google Scholar]
  9. Melnick J. L., Dreesman G. R., Hollinger F. B. Approaching the control of viral hepatitis type B. J Infect Dis. 1976 Feb;133(2):210–229. doi: 10.1093/infdis/133.2.210. [DOI] [PubMed] [Google Scholar]
  10. Moriarty A. M., Hoyer B. H., Shih J. W., Gerin J. L., Hamer D. H. Expression of the hepatitis B virus surface antigen gene in cell culture by using a simian virus 40 vector. Proc Natl Acad Sci U S A. 1981 Apr;78(4):2606–2610. doi: 10.1073/pnas.78.4.2606. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Peterson D. L. Isolation and characterization of the major protein and glycoprotein of hepatitis B surface antigen. J Biol Chem. 1981 Jul 10;256(13):6975–6983. [PubMed] [Google Scholar]
  12. Prince A. M., Ikram H., Hopp T. P. Hepatitis B virus vaccine: identification of HBsAg/a and HBsAg/d but not HBsAg/y subtype antigenic determinants on a synthetic immunogenic peptide. Proc Natl Acad Sci U S A. 1982 Jan;79(2):579–582. doi: 10.1073/pnas.79.2.579. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Sanchez Y., Ionescu-Matiu I. I., Sparrow J. T., Melnick J. L., Dreesman G. R. Immunogenicity of conjugates and micelles of synthetic hepatitis B surface antigen peptides. Intervirology. 1982;18(4):209–213. doi: 10.1159/000149327. [DOI] [PubMed] [Google Scholar]
  14. Sukeno N., Shirachi R., Yamaguchi J., Ishida N. Reduction and reoxidation of Australia antigen: loss and reconstitution of particle structure and antigenicity. J Virol. 1972 Jan;9(1):182–183. doi: 10.1128/jvi.9.1.182-183.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Tiollais P., Charnay P., Vyas G. N. Biology of hepatitis B virus. Science. 1981 Jul 24;213(4506):406–411. doi: 10.1126/science.6264599. [DOI] [PubMed] [Google Scholar]
  16. Vyas G. N., Rao K. R., Ibrahim A. B. Australia antigen (hepatitis B antigen): a conformational antigen dependent on disulfide bonds. Science. 1972 Dec 22;178(4067):1300–1301. doi: 10.1126/science.178.4067.1300. [DOI] [PubMed] [Google Scholar]

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