Skip to main content
Journal of Virology logoLink to Journal of Virology
. 1987 Jan;61(1):81–86. doi: 10.1128/jvi.61.1.81-86.1987

Studies on the sequential development of acute interstitial pneumonia caused by Aleutian disease virus in mink kits.

S Alexandersen, M E Bloom
PMCID: PMC255207  PMID: 3023709

Abstract

We studied different parameters during the development of acute interstitial pneumonia in mink kits caused by neonatal infection with Aleutian disease virus (ADV). When histological lesions, presence of intranuclear inclusion bodies, and intranuclearly localized ADV antigen were correlated with levels of single-stranded virion and duplex replicative forms of ADV DNA in the different tissues, it was concluded that the lung, probably alveolar type II cells, is the major primary target for viral replication and cytopathology. The presence of the duplex dimeric replicative-form DNA, a strong marker of parvovirus replication, was also observed in low amount in the mesenteric lymph node, suggesting replication of ADV in this organ, although no viral cytopathology could be demonstrated. Moreover, a few intranuclear inclusion bodies were demonstrated in kidney and liver from affected kits, but intranuclearly localized ADV antigen could not be demonstrated in liver sections, and neither could duplex dimer replicative-form DNA, suggesting that these organs are nevertheless not a major site of ADV replication. When the data were compared with results previously reported for ADV-infected adult mink and ADV-infected permissive cell cultures, the data suggested that the pattern of ADV replication in alveolar type II cells is similar to that seen in infected cell cultures but that the replication in the other kit organs resembles the restricted pattern seen in adult mink.

Full text

PDF
81

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aasted B., Race R. E., Bloom M. E. Aleutian disease virus, a parvovirus, is proteolytically degraded during in vivo infection in mink. J Virol. 1984 Jul;51(1):7–13. doi: 10.1128/jvi.51.1.7-13.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Alexandersen S. Acute interstitial pneumonia in mink kits: experimental reproduction of the disease. Vet Pathol. 1986 Sep;23(5):579–588. doi: 10.1177/030098588602300506. [DOI] [PubMed] [Google Scholar]
  3. Alexandersen S., Hau J., Larsen S. Examination of Aleutian disease virus in charge-shift crossed immunoelectrophoresis. Acta Pathol Microbiol Immunol Scand B. 1984 Dec;92(6):331–334. doi: 10.1111/j.1699-0463.1984.tb02842.x. [DOI] [PubMed] [Google Scholar]
  4. Alexandersen S., Hau J. Rocket line immunoelectrophoresis: an improved assay for simultaneous quantification of a mink parvovirus (Aleutian disease virus) antigen and antibody. J Virol Methods. 1985 Feb;10(2):145–151. doi: 10.1016/0166-0934(85)90100-4. [DOI] [PubMed] [Google Scholar]
  5. Alexandersen S., Uttenthal-Jensen A., Aasted B. Demonstration of non-degraded Aleutian disease virus (ADV) proteins in lung tissue from experimentally infected mink kits. Brief report. Arch Virol. 1986;87(1-2):127–133. doi: 10.1007/BF01310549. [DOI] [PubMed] [Google Scholar]
  6. Bloom M. E., Race R. E., Aasted B., Wolfinbarger J. B. Analysis of Aleutian disease virus infection in vitro and in vivo: demonstration of Aleutian disease virus DNA in tissues of infected mink. J Virol. 1985 Sep;55(3):696–703. doi: 10.1128/jvi.55.3.696-703.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bloom M. E., Race R. E., Wolfinbarger J. B. Characterization of Aleutian disease virus as a parvovirus. J Virol. 1980 Sep;35(3):836–843. doi: 10.1128/jvi.35.3.836-843.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Chesebro B., Bloom M., Hadlow W., Race R. Purification and ultrastructure of Aleutian disease virus of mink. Nature. 1975 Apr 3;254(5499):456–457. doi: 10.1038/254456a0. [DOI] [PubMed] [Google Scholar]
  9. Cho H. J., Ingram D. G. Antigen and antibody in Aleutian disease in mink. I. Precipitation reaction by agar-gel electrophoresis. J Immunol. 1972 Feb;108(2):555–557. [PubMed] [Google Scholar]
  10. Coe J. E., Race R. E. Ontogeny of mink IgG, IgA, and IgM. Proc Soc Exp Biol Med. 1978 Feb;157(2):289–292. doi: 10.3181/00379727-157-40039. [DOI] [PubMed] [Google Scholar]
  11. Evans M. J., Johnson L. V., Stephens R. J., Freeman G. Cell renewal in the lungs of rats exposed to low levels of ozone. Exp Mol Pathol. 1976 Feb;24(1):70–83. doi: 10.1016/0014-4800(76)90058-7. [DOI] [PubMed] [Google Scholar]
  12. Gillett D. G., Ford G. T. Drug-induced lung disease. Monogr Pathol. 1978;19:21–42. [PubMed] [Google Scholar]
  13. Hadlow W. J., Race R. E., Kennedy R. C. Comparative pathogenicity of four strains of Aleutian disease virus for pastel and sapphire mink. Infect Immun. 1983 Sep;41(3):1016–1023. doi: 10.1128/iai.41.3.1016-1023.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Hahn E. C. Immune complexes in Aleutian disease: demonstration of antibody on isolated virus. Vet Immunol Immunopathol. 1984 Mar;5(4):313–321. doi: 10.1016/0165-2427(84)90001-1. [DOI] [PubMed] [Google Scholar]
  15. Haies D. M., Gil J., Weibel E. R. Morphometric study of rat lung cells. I. Numerical and dimensional characteristics of parenchymal cell population. Am Rev Respir Dis. 1981 May;123(5):533–541. doi: 10.1164/arrd.1981.123.5.533. [DOI] [PubMed] [Google Scholar]
  16. Kauffman S. L. Cell proliferation in the mammalian lung. Int Rev Exp Pathol. 1980;22:131–191. [PubMed] [Google Scholar]
  17. Kuhn C., 3rd Ultrastructure and cellular function in the distal lung. Monogr Pathol. 1978;19:1–20. [PubMed] [Google Scholar]
  18. Larsen S., Alexandersen S., Lund E., Have P., Hansen M. Acute interstitial pneumonitis caused by Aleutian disease virus in mink kits. Acta Pathol Microbiol Immunol Scand A. 1984 Sep;92(5):391–393. doi: 10.1111/j.1699-0463.1984.tb04419.x. [DOI] [PubMed] [Google Scholar]
  19. Lenghaus C., Studdert M. J. Generalized parvovirus disease in neonatal pups. J Am Vet Med Assoc. 1982 Jul 1;181(1):41–45. [PubMed] [Google Scholar]
  20. PORTER D. D. TRANSFER OF GAMMA GLOBULIN FROM MOTHER TO OFFSPRING IN MINK. Proc Soc Exp Biol Med. 1965 May;119:131–133. doi: 10.3181/00379727-119-30117. [DOI] [PubMed] [Google Scholar]
  21. Porter D. D., Larsen A. E., Porter H. G. Aleutian disease of mink. Adv Immunol. 1980;29:261–286. doi: 10.1016/s0065-2776(08)60046-2. [DOI] [PubMed] [Google Scholar]
  22. Porter D. D., Larsen A. E., Porter H. G. The pathogenesis of Aleutian disease of mink. 3. Immune complex arteritis. Am J Pathol. 1973 May;71(2):331–344. [PMC free article] [PubMed] [Google Scholar]
  23. Porter D. D., Larsen A. E., Porter H. G. The pathogenesis of Aleutian disease of mink. I. In vivo viral replication and the host antibody response to viral antigen. J Exp Med. 1969 Sep 1;130(3):575–593. doi: 10.1084/jem.130.3.575. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Race R. E., Chesebro B., Bloom M. E., Aasted B., Wolfinbarger J. Monoclonal antibodies against Aleutian disease virus distinguish virus strains and differentiate sites of virus replication from sites of viral antigen sequestration. J Virol. 1986 Jan;57(1):285–293. doi: 10.1128/jvi.57.1.285-293.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Southern E. Gel electrophoresis of restriction fragments. Methods Enzymol. 1979;68:152–176. doi: 10.1016/0076-6879(79)68011-4. [DOI] [PubMed] [Google Scholar]
  26. Tattersall P., Bratton J. Reciprocal productive and restrictive virus-cell interactions of immunosuppressive and prototype strains of minute virus of mice. J Virol. 1983 Jun;46(3):944–955. doi: 10.1128/jvi.46.3.944-955.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES