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Journal of Virology logoLink to Journal of Virology
. 1987 Jan;61(1):209–213. doi: 10.1128/jvi.61.1.209-213.1987

Productive, persistent infection of human colorectal cell lines with human immunodeficiency virus.

A Adachi, S Koenig, H E Gendelman, D Daugherty, S Gattoni-Celli, A S Fauci, M A Martin
PMCID: PMC255241  PMID: 3640832

Abstract

Thirteen adherent human non-lymphocyte cell lines were tested for their susceptibility to infection by human immunodeficiency virus. Productive infection could be demonstrated in three of five colorectal carcinoma cell lines examined; the other eight human non-lymphocyte cell lines were uninfectible. A susceptible colon carcinoma cell line (HT29), as well as normal colonic mucosa, was shown to contain a 3.0-kilobase species of poly(A)+ CD4 RNA, whereas uninfectible colon carcinoma and rhabdomyosarcoma cell lines synthesized no detectable T4 RNA. A persistently infected colon carcinoma cell line was established that continued to produce progeny human immunodeficiency virus for more than 10 weeks postinfection.

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Selected References

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