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. 1987 Jan;61(1):218–220. doi: 10.1128/jvi.61.1.218-220.1987

A new common integration region (int-3) for mouse mammary tumor virus on mouse chromosome 17.

D Gallahan, C Kozak, R Callahan
PMCID: PMC255246  PMID: 3023699

Abstract

Mus musculus subsp. musculus (Czech II) mammary tumor DNA frequently contains an integrated proviral genome of the mouse mammary tumor virus (MMTV) within a specific 0.5-kilobase-pair region of the cellular genome (designated int-3). Viral integration at this site results in activation of expression of an adjacent cellular gene. We mapped int-3 to mouse chromosome 17 by analysis of PstI-restricted cellular DNAs from mouse-hamster somatic cell hybrids. Restriction analysis of cellular DNA from (C3H/OuJ X Czech II) X Czech II backcross mice established the gene order T-H-2-int-3. These results demonstrated that the int-3 locus is distinct from two other common integration regions for mouse mammary tumor virus (designated int-1 and int-2) in mammary tumor DNA and suggest that several cellular genes may be at risk for virally induced activation during mammary tumor development.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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