Abstract
Ribavirin (1-beta-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide) eliminates foot-and-mouth disease virus from persistently infected cell cultures. The latter are 10-fold more sensitive to ribavirin than lytically infected cells. In treated cells no viral RNA or proteins could be detected by dot-blot hybridization to cDNA probes, virus and RNA infectivity assays, or immunofluorescence. A potential application of the drug for the treatment of animals carrying the virus is suggested.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bachrach H. L. Foot-and-mouth disease. Annu Rev Microbiol. 1968;22:201–244. doi: 10.1146/annurev.mi.22.100168.001221. [DOI] [PubMed] [Google Scholar]
- Bachrach H. L. Ribonucleic acid of foot-and-mouth disease virus: an ultrasensitive plaque assay. Proc Soc Exp Biol Med. 1966 Dec;123(3):939–945. doi: 10.3181/00379727-123-31644. [DOI] [PubMed] [Google Scholar]
- Holland J., Spindler K., Horodyski F., Grabau E., Nichol S., VandePol S. Rapid evolution of RNA genomes. Science. 1982 Mar 26;215(4540):1577–1585. doi: 10.1126/science.7041255. [DOI] [PubMed] [Google Scholar]
- Martínez-Salas E., Ortín J., Domingo E. Sequence of the viral replicase gene from foot-and-mouth disease virus C1-Santa Pau (C-S8). Gene. 1985;35(1-2):55–61. doi: 10.1016/0378-1119(85)90157-x. [DOI] [PubMed] [Google Scholar]
- McCammon J. R., Riesser V. W. Effects of ribavirin on BHK-21 cells acutely or persistently infected with mumps virus. Antimicrob Agents Chemother. 1979 Mar;15(3):356–360. doi: 10.1128/aac.15.3.356. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sompayrac L. M., Danna K. J. Efficient infection of monkey cells with DNA of simian virus 40. Proc Natl Acad Sci U S A. 1981 Dec;78(12):7575–7578. doi: 10.1073/pnas.78.12.7575. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sutmoller P., McVicar J. W., Cottral G. E. The epizootiological importance of foot-and-mouth disease carriers. I. Experimentally produced foot-and-mouth disease carriers in susceptible and immune cattle. Arch Gesamte Virusforsch. 1968;23(3):227–235. doi: 10.1007/BF01241895. [DOI] [PubMed] [Google Scholar]
- de la Torre J. C., Dávila M., Sobrino F., Ortín J., Domingo E. Establishment of cell lines persistently infected with foot-and-mouth disease virus. Virology. 1985 Aug;145(1):24–35. doi: 10.1016/0042-6822(85)90198-9. [DOI] [PubMed] [Google Scholar]