Abstract
Aqueous solutions of oxyhemoglobin were irradiated with 80 Mev neutrons with doses of 0.9 Mrads and 1,400 rads. Spectrophotometric measurements were made on the irradiated solutions. Absorption measurements for the 0.9-Mrad irradiation indicated that oxyhemoglobin was converted into methemoglobin and that porphyrin molecules were destroyed. The 1,400-rad irradiation gave no measureable conversion of oxyhemoglobin into methemoglobin. There was, however, destruction of some of the oxyhemoglobin.
Results indicated that high-energy neutron irradiation causes structural alteration of the hemoglobin molecule and that this alteration is similar to that found for gamma and x-rays.
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Selected References
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- AMBE K. S., KUMTA U. S., TAPPEL A. L. Radiation damage to cytochrome c and hemoglobin. Radiat Res. 1961 Dec;15:709–719. [PubMed] [Google Scholar]
- BARRON E. S. G., JOHNSON P. Studies on the mechanism of action of ionizing radiations. XV. X-irradiation of oxyhemoglobin and related compounds. Radiat Res. 1956 Sep;5(3):290–302. [PubMed] [Google Scholar]
- LASER H. Effect of ionizing radiation on haemoglobin and cytochrome c. Nature. 1955 Aug 20;176(4477):361–362. doi: 10.1038/176361a0. [DOI] [PubMed] [Google Scholar]
- LASER H. The oxygen-effect in ionizing irradiation. Nature. 1954 Oct 16;174(4433):753–753. doi: 10.1038/174753a0. [DOI] [PubMed] [Google Scholar]
- Szweda-Lewandowska Z., Puchala M., Leyko W. Effects of gamma irradiation of the structure and function of human hemoglobin. Radiat Res. 1976 Jan;65(1):50–59. [PubMed] [Google Scholar]