Abstract
The data of the Third National Cancer Survey show for many cancer types, large differences in cancer incidence between Euro-Americans and Afro-Americans.1 As in other racial studies, it is difficult to separate environmental and genetic factors. For the cancers which are more frequent among Afro-Americans, environmental factors seem to be primarily responsible. However, among the cancers less frequent in Afro-Americans, there are some for which the racial differences have a genetic basis. This is clearly the case for skin and lip cancers caused by the ultraviolet B of the sun. Genetic factors are probably also responsible for the racial differences in the incidence of malignant melanomas, testis cancers, astrocytomas, and Ewing's sarcomas. Perhaps there is also a genetic basis for some of the racial differences in the incidence of malignant lymphomas and leukemias. For all these cancers, Afro-Americans are less susceptible. The only cancer to which Afro-Americans appear more susceptible on the basis of genetic makeup, is fibrosarcoma. This is in accord with the high frequency of keloids, a benign counterpart of fibrosarcoma in Afro-Americans.
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Selected References
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- Fan K. J., Kovi J., Earle K. M. The ethnic distribution of primary central nervous system tumors: AFIP, 1958 to 1970. J Neuropathol Exp Neurol. 1977 Jan;36(1):41–49. doi: 10.1097/00005072-197701000-00005. [DOI] [PubMed] [Google Scholar]
- Fontaine S. A., Henschke U. K., Leffall L. D., Jr, Mason C. H., Reinhold A. W., Schneider R., White J. E. Comparison of the cancer deaths in the black and white U.S.A. population from 1949 to 1967. Med Ann Dist Columbia. 1972 May;41(5):293–298. [PubMed] [Google Scholar]
- Henschke U. K., Leffall L. D., Jr, Mason C. H., Reinhold A. W., Schneider R. L., White J. E. Alarming increase of the cancer mortality in the U.S. black population (1950-1967). Cancer. 1973 Apr;31(4):763–768. doi: 10.1002/1097-0142(197304)31:4<763::aid-cncr2820310401>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
- Heshmat M. Y., Kovi J., Simpson C., Kennedy J., Fan K. J. Neoplasms of the central nervous system. incidence and population selectivity in the Washington DC, metropolitan area. Cancer. 1976 Nov;38(5):2135–2142. doi: 10.1002/1097-0142(197611)38:5<2135::aid-cncr2820380543>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
- WHITE J. E., STRUDWICK W. J., RICKETTS W. N., SAMPSON C. Cancer of the skin in Negroes. A review of 31 cases. JAMA. 1961 Nov 25;178:845–847. doi: 10.1001/jama.1961.73040470023015b. [DOI] [PubMed] [Google Scholar]