Abstract
An elderly patient with simultaneous hyperparathyroidism and light chain myeloma is described. The patient presented with hypercalcemia, bone pain, pathologic fractures, and cystic and lytic bone lesions. The problems of diagnosis and management are discussed. It is recommended that elderly patients with hypercalcemia and bone lesions should have not only diagnostic studies for hyperparathyroidism but also serum and urine immunoelectrophoresis to detect multiple myeloma or plasma cell neoplastic variants. Surgery is indicated for the hyperparathyroidism. Chemotherapy and localized radiotherapy usually control the myelomatous disease.
Full text
PDFImages in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Boonstra C. E., Jackson C. E. Serum calcium survey for hyperparathyroidism: results in 50,000 clinic patients. Am J Clin Pathol. 1971 May;55(5):523–526. doi: 10.1093/ajcp/55.5.523. [DOI] [PubMed] [Google Scholar]
- Dexter R. N., Mullinax F., Estep H. L., Williams R. C., Jr Monoclonal IgG gammopathy and hyperparathyroidism. Ann Intern Med. 1972 Nov;77(5):759–764. doi: 10.7326/0003-4819-77-5-759. [DOI] [PubMed] [Google Scholar]
- Heath H., 3rd, Hodgson S. F., Kennedy M. A. Primary hyperparathyroidism. Incidence, morbidity, and potential economic impact in a community. N Engl J Med. 1980 Jan 24;302(4):189–193. doi: 10.1056/NEJM198001243020402. [DOI] [PubMed] [Google Scholar]
- Johansson H., Werner I. Letter: Dysproteinemia, malignancy, and hyperparathyroidism. Ann Intern Med. 1975 Jul;83(1):121–122. doi: 10.7326/0003-4819-83-1-121_2. [DOI] [PubMed] [Google Scholar]
- Robins S. M., Chopra D. Multiple myeloma and multiple neoplasms. JAMA. 1976 Oct 4;236(14):1609–1609. [PubMed] [Google Scholar]
- Williams R. C., Jr, Brunning R. D., Wollheim F. A. Light-chain disease. An abortive variant of multiple myeloma. Ann Intern Med. 1966 Sep;65(3):471–486. doi: 10.7326/0003-4819-65-3-471. [DOI] [PubMed] [Google Scholar]