Abstract
A subspecialty clinic was established in a large city hospital in order to evaluate and treat patients with chest pain syndromes and to assess the relative efficiency of isosorbide dinitrate and propranolol in the treatment of angina pectoris. The intensive subspecialty approach proved superior to the standard evaluation and treatment that these patients received in the general medicine clinics. Almost 50 percent of referred patients with the diagnosis of longstanding angina pectoris did not have this disease. Of the patients with chest pain due to coronary artery disease, the clinic provided an expedient, efficient, and effective means of evaluation and treatment. Isosorbide dinitrate was shown to be as effective an antianginal drug as propranolol.
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Selected References
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- Aronow W. S. Clinical use of nitrates. I. Nitrates as antianginal drugs. Mod Concepts Cardiovasc Dis. 1979 Jun;48(6):31–35. [PubMed] [Google Scholar]
- Bemiller C. R., Pepine C. J., Rogers A. K. Long-term observations in patients with angina and normal coronary arteriograms. Circulation. 1973 Jan;47(1):36–43. doi: 10.1161/01.cir.47.1.36. [DOI] [PubMed] [Google Scholar]
- Day L. J., Sowton E. Clinical features and follow-up of patients with angina and normal coronary arteries. Lancet. 1976 Aug 14;2(7981):334–337. doi: 10.1016/s0140-6736(76)92591-5. [DOI] [PubMed] [Google Scholar]
- Dwyer E. M., Jr, Wiener L., Cox J. W. Angina pectoris in patients with normal and abnormal coronary arteriograms. Am J Cardiol. 1969 May;23(5):639–646. doi: 10.1016/0002-9149(69)90024-1. [DOI] [PubMed] [Google Scholar]
- Furberg B., Dahlqvist A., Raak A., Wrege U. Comparison of the new beta-adrenoceptor antagonist, nadolol, and propranolol in the treatment of angina pectoris. Curr Med Res Opin. 1978;5(5):388–393. doi: 10.1185/03007997809111903. [DOI] [PubMed] [Google Scholar]
- Glancy D. L., Richter M. A. Medical management of patients with angina pectoris. J La State Med Soc. 1978 Feb;130(2):31–37. [PubMed] [Google Scholar]
- Ikram H. Angina pectoris: current approach to treatment. Drugs. 1979 Aug;18(2):130–136. doi: 10.2165/00003495-197918020-00005. [DOI] [PubMed] [Google Scholar]
- Jackson G., Richardson P. J., Atkinson L., Armstrong P., Oram S. Angina with normal coronary arteriograms. Value of coronary sinus lactate estimation in diagnosis and treatment. Br Heart J. 1978 Sep;40(9):976–978. doi: 10.1136/hrt.40.9.976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kannel W. B., Sorlie P. D. Remission of clinical angina pectoris: the Framingham study. Am J Cardiol. 1978 Jul;42(1):119–123. doi: 10.1016/0002-9149(78)90995-5. [DOI] [PubMed] [Google Scholar]
- Kaverina N. V., Chumburidze V. B. Antianginal drugs. Pharmacol Ther. 1979;4(1):109–153. doi: 10.1016/0163-7258(79)90017-2. [DOI] [PubMed] [Google Scholar]
- Kemp H. G., Elliott W. C., Gorlin R. The anginal syndrome with normal coronary arteriography. Trans Assoc Am Physicians. 1967;80:59–70. [PubMed] [Google Scholar]
- Kemp H. G., Jr, Vokonas P. S., Cohn P. F., Gorlin R. The anginal syndrome associated with normal coronary arteriograms. Report of a six year experience. Am J Med. 1973 Jun;54(6):735–742. doi: 10.1016/0002-9343(73)90060-0. [DOI] [PubMed] [Google Scholar]
- Luchi R. J., Chahine R. A., Raizner A. E. Coronary artery spasm. Ann Intern Med. 1979 Sep;91(3):441–449. doi: 10.7326/0003-4819-91-3-441. [DOI] [PubMed] [Google Scholar]
- Mason J. W., Strefling A. Small vessel disease of the heart resulting in myocardial necrosis and death despite angiographically normal coronary arteries. Am J Cardiol. 1979 Jul;44(1):171–176. doi: 10.1016/0002-9149(79)90267-4. [DOI] [PubMed] [Google Scholar]
- Shand D. G. Drug therapy: Propranolol. N Engl J Med. 1975 Aug 7;293(6):280–285. doi: 10.1056/NEJM197508072930606. [DOI] [PubMed] [Google Scholar]
- Short D. Angina. Br Med J. 1978 Sep 30;2(6142):939–940. doi: 10.1136/bmj.2.6142.939. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sostman H. D., Langou R. A. Contemporary medical management of stable angina pectoris. Am Heart J. 1978 Jun;95(6):775–788. doi: 10.1016/0002-8703(78)90510-0. [DOI] [PubMed] [Google Scholar]
- Strong J. P. Atherosclerosis in human populations. Atherosclerosis. 1972 Sep-Oct;16(2):193–201. doi: 10.1016/0021-9150(72)90053-6. [DOI] [PubMed] [Google Scholar]
- Waxler E. B., Kimbiris D., Dreifus L. S. The fate of women with normal coronary arteriograms and chest pain resembling angina pectoris. Am J Cardiol. 1971 Jul;28(1):25–32. doi: 10.1016/0002-9149(71)90030-0. [DOI] [PubMed] [Google Scholar]
- Wiener L., Kasparian H., Duca P. R., Walinsky P., Gottlieb R. S., Hanckel F., Brest A. N. Spectrum of coronary arterial spasm. Clinical, angiographic and myocardial metabolic experience in 29 cases. Am J Cardiol. 1976 Dec;38(7):945–955. doi: 10.1016/0002-9149(76)90808-0. [DOI] [PubMed] [Google Scholar]
