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. 1982 Apr;74(4):339–343.

Adult Nephrotic Syndrome and Acquired Coagulopathies: Hageman Factor Deficiency

Herman E Branson, N Dabir Vaziri, Lewis M Slater
PMCID: PMC2552871  PMID: 7120469

Abstract

Analysis of tests of coagulation and fibrinolysis from 20 adult nephrotics prior to the onset of therapy disclosed that 40 percent had low factor XII levels. The mean factor XI was normal. The platelet count and fibrinogen concentration were elevated. The findings of this study on adults are similar to those of Honig and Lindley21 in the nephrotic syndrome of childhood. Subjects with minimal change disease constituted a small (15 percent) but readily segregated subpopulation without evidence of fibrinolysis in association with low factor XII activity. Prolongation of the activated partial thromboplastin time corresponded in every instance with factor XII activities of ≤30 percent. Lengthening of the one stage prothrombin time was not directly attributable to factor deficiencies.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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