Abstract
The allele Mx regulates the extent to which interferon alpha/beta inhibits the growth of influenza viruses in mouse cells such as peritoneal macrophages. The time course of induction of the antiviral state against an influenza A virus is comparable in macrophages with and without Mx and is similar to that found with vesicular stomatitis virus. In contrast, the decay of the antiviral state against influenza virus is markedly slower in Mx-positive cells and slower than that against vesicular stomatitis virus observed in either Mx-positive or Mx-negative cells. Thus, after removal of interferon alpha/beta, Mx-positive cells remain protected against influenza virus at times when they have lost protection against vesicular stomatitis virus. These results suggest that interferon alpha/beta treatment activates different antiviral mechanisms, each acting against distinct groups of viruses and each independently controlled by host genes.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Arnheiter H., Haller O., Lindenmann J. Host gene influence on interferon action in adult mouse hepatocytes: specificity for influenza virus. Virology. 1980 May;103(1):11–20. doi: 10.1016/0042-6822(80)90122-1. [DOI] [PubMed] [Google Scholar]
- Colonno R. J., Pang R. H. Induction of unique mRNAs by human interferons. J Biol Chem. 1982 Aug 25;257(16):9234–9237. [PubMed] [Google Scholar]
- Gresser I., Tovey M. G., Bandu M. E., Maury C., Brouty-Boyé D. Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. I. Rapid evolution of encephalomyocarditis virus infection. J Exp Med. 1976 Nov 2;144(5):1305–1315. doi: 10.1084/jem.144.5.1305. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Haller O., Arnheiter H., Gresser I., Lindenmann J. Genetically determined, interferon-dependent resistance to influenza virus in mice. J Exp Med. 1979 Mar 1;149(3):601–612. doi: 10.1084/jem.149.3.601. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Haller O., Arnheiter H., Horisberger M. A., Gresser I., Lindenmann J. Interaction between interferon and host genes in antiviral defense. Ann N Y Acad Sci. 1980;350:558–565. doi: 10.1111/j.1749-6632.1980.tb20657.x. [DOI] [PubMed] [Google Scholar]
- Haller O., Arnheiter H., Lindenmann J., Gresser I. Host gene influences sensitivity to interferon action selectively for influenza virus. Nature. 1980 Feb 14;283(5748):660–662. doi: 10.1038/283660a0. [DOI] [PubMed] [Google Scholar]
- Haller O. Inborn resistance of ice to orthomyxoviruses. Curr Top Microbiol Immunol. 1981;92:25–52. doi: 10.1007/978-3-642-68069-4_3. [DOI] [PubMed] [Google Scholar]
- Hallum J. V., Thacore H. R., Youngner J. S. Factors affecting the sensitivity of different viruses to interferon. J Virol. 1970 Aug;6(2):156–162. doi: 10.1128/jvi.6.2.156-162.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Krishnan I., Baglioni C. Regulation of 2'5'-oligo(A) polymerase activity in quiescent human fibroblasts treated with interferon. Virology. 1981 Jun;111(2):666–670. doi: 10.1016/0042-6822(81)90368-8. [DOI] [PubMed] [Google Scholar]
- LINDENMANN J., LANE C. A., HOBSON D. THE RESISTANCE OF A2G MICE TO MYXOVIRUSES. J Immunol. 1963 Jun;90:942–951. [PubMed] [Google Scholar]
- Lengyel P. Biochemistry of interferons and their actions. Annu Rev Biochem. 1982;51:251–282. doi: 10.1146/annurev.bi.51.070182.001343. [DOI] [PubMed] [Google Scholar]
- Lindenmann J., Deuel E., Fanconi S., Haller O. Inborn resistance of mice to myxoviruses: macrophages express phenotype in vitro. J Exp Med. 1978 Feb 1;147(2):531–540. doi: 10.1084/jem.147.2.531. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Samuel C. E., Knutson G. S. Mechanism of interferon action. Kinetics of decay of the antiviral state and protein phosphorylation in mouse fibroblasts treated with natural and cloned interferons. J Biol Chem. 1982 Oct 10;257(19):11796–11801. [PubMed] [Google Scholar]
- Tovey M. G., Begon-Lours J., Gresser I. A method for the large scale production of potent interferon preparations. Proc Soc Exp Biol Med. 1974 Jul;146(3):809–815. doi: 10.3181/00379727-146-38196. [DOI] [PubMed] [Google Scholar]