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. 1983 Sep;47(3):637–641. doi: 10.1128/jvi.47.3.637-641.1983

Blockage of antiviral induction of interferon by homologous cell biochemical activity: effect of chicken embryo fibroblast mitotic cell cycle phases on Sindbis virus growth.

V A Ghubril
PMCID: PMC255305  PMID: 6620465

Abstract

The antiviral activity of interferon, measured as the reduction of viral yield, was studied as a function of the cell cycle phases. The present study shows that cells which are about to enter DNA replication phase S and cells that are in mitosis phase M are not refractive to viral infection when treated with interferon. The growth of Sindbis virus, used as the challenger, dropped considerably at the G1-S junction, at mitosis phase M, and as cells entered into a deeper quiescent state.

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Selected References

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