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Journal of Virology logoLink to Journal of Virology
. 1983 Nov;48(2):405–409. doi: 10.1128/jvi.48.2.405-409.1983

Suppression of a VP1 mutant of simian virus 40 by missense mutations in serine codons of the viral agnogene.

R F Margolskee, D Nathans
PMCID: PMC255365  PMID: 6312098

Abstract

We isolated second-site revertants of a partially defective VP1 mutant of simian virus 40. The suppressing mutation in each of these pseudorevertants was mapped to the viral agnogene. Of six independently isolated pseudorevertants, all had a missense mutation in a serine codon, near the beginning of the agnogene, that would cause replacement of serine at position 7, 11, or 17 in the agnoprotein by a hydrophobic amino acid. Our results suggest that the agnoprotein interacts in a specific way with VP1 during the late stages of viral development.

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Selected References

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