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. 1983 Nov;48(2):410–418. doi: 10.1128/jvi.48.2.410-418.1983

Host range mutants of human rhinovirus in which nonstructural proteins are altered.

F H Yin, N B Lomax
PMCID: PMC255366  PMID: 6312099

Abstract

Human rhinovirus type 2 did not replicate in nonpermissive mouse cells; the restriction was not in adsorption but in the early events of virus replication. Mutants which had been adapted to grow in mouse cells had the following characteristics: (i) no change in the structural protein, (ii) a larger nonstructural protein and its precursor protein, and (iii) an altered viral RNA synthesis. The altered nonstructural proteins correlated with a change in host range of the virus and may be involved in viral RNA synthesis.

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Selected References

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