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. 1983 Dec;48(3):565–572. doi: 10.1128/jvi.48.3.565-572.1983

Transduction of c-myb into avian myeloblastosis virus: locating points of recombination within the cellular gene.

K H Klempnauer, J M Bishop
PMCID: PMC255387  PMID: 6195355

Abstract

The oncogene (v-myb) of avian myeloblastosis virus apparently arose by transduction of nucleotide sequences from a cellular gene (c-myb). In c-myb the nucleotide sequences that formed v-myb exist at seven distinct regions separated by nontransduced stretches of sequence that are flanked by eucaryotic splice signals. By contrast, the sequences at the outside boundaries of the transduced region of c-myb do not resemble splice sites. We mapped the nucleotide sequences that are homologous to the ends of v-myb with respect to the exons and introns of c-myb. The results indicate that the leftward recombination between c-myb and the transducing retrovirus occurred within an intron of the cellular gene, whereas the rightward recombination took place in an exon of c-myb. Transduction of c-myb sequences may therefore have involved a DNA rearrangement.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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