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. 1953;8(5-6):725–741.

Vaccination against influenza*

Thomas Francis jr
PMCID: PMC2554195  PMID: 13094502

Abstract

This paper reviews studies which have been carried out during the past twenty years in the United States of America to investigate the suitability of various vaccines and vaccination methods for immunizing man against the different influenza virus strains. A number of investigations in closed communities, such as children's institutions, army and navy units, and medical schools, are described. The author discusses the comparative value of the techniques employed in preparing vaccines, and the use of adjuvants in improving the response.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown J. W., Eaton M. D., Meiklejohn G., Lagen J. B., Kerr W. J. AN EPIDEMIC OF INFLUENZA. RESULTS OF PROPHYLACTIC INOCULATION OF A COMPLEX INFLUENZA A-DISTEMPER VACCINE. J Clin Invest. 1941 Nov;20(6):663–669. doi: 10.1172/JCI101259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. FRANCIS T., Jr Significance of antigenic variation of influenza viruses in relation to vaccination in man. Fed Proc. 1952 Sep;11(3):808–812. [PubMed] [Google Scholar]
  3. Francis T., Jr, Salk J. E. A SIMPLIFIED PROCEDURE FOR THE CONCENTRATION AND PURIFICATION OF INFLUENZA VIRUS. Science. 1942 Nov 27;96(2500):499–500. doi: 10.1126/science.96.2500.499. [DOI] [PubMed] [Google Scholar]
  4. Francis T., Magill T. P. THE ANTIBODY RESPONSE OF HUMAN SUBJECTS VACCINATED WITH THE VIRUS OF HUMAN INFLUENZA. J Exp Med. 1937 Jan 31;65(2):251–259. doi: 10.1084/jem.65.2.251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Francis T. QUANTITATIVE RELATIONSHIPS BETWEEN THE IMMUNIZING DOSE OF EPIDEMIC INFLUENZA VIRUS AND THE RESULTANT IMMUNITY. J Exp Med. 1939 Jan 31;69(2):283–300. doi: 10.1084/jem.69.2.283. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Francis T., Salk J. E., Pearson H. E., Brown P. N. PROTECTIVE EFFECT OF VACCINATION AGAINST INDUCED INFLUENZA A. J Clin Invest. 1945 Jul;24(4):536–546. doi: 10.1172/JCI101633. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Francis T., Salk J. E., Quilligan J. J. Experience with Vaccination Against Influenza in the Spring of 1947: A Preliminary Report. Am J Public Health Nations Health. 1947 Aug;37(8):1013–1016. doi: 10.2105/ajph.37.8.1013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hirst G. K. ADSORPTION OF INFLUENZA HEMAGGLUTININS AND VIRUS BY RED BLOOD CELLS. J Exp Med. 1942 Aug 1;76(2):195–209. doi: 10.1084/jem.76.2.195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hirst G. K., Rickard E. R., Whitman L., Horsfall F. L. ANTIBODY RESPONSE OF HUMAN BEINGS FOLLOWING VACCINATION WITH INFLUENZA VIRUSES. J Exp Med. 1942 May 1;75(5):495–511. doi: 10.1084/jem.75.5.495. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Horsfall F. L., Rickard E. R. NEUTRALIZING ANTIBODIES IN HUMAN SERUM AFTER INFLUENZA A : THE LACK OF STRAIN SPECIFICITY IN THE IMMUNOLOGICAL RESPONSE. J Exp Med. 1941 Oct 31;74(5):433–439. doi: 10.1084/jem.74.5.433. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. MEIKLEJOHN G., KEMPE C. H., THALMAN W. G., LENNETTE E. H. Evaluation of monovalent influenza vaccines. II. Observations during an influenza a-prime epidemic. Am J Hyg. 1952 Jan;55(1):12–21. doi: 10.1093/oxfordjournals.aje.a119500. [DOI] [PubMed] [Google Scholar]
  12. MEIKLEJOHN G., WEISS D. L., SHRAGG R. I., LENNETTE E. H. Evaluation of monovalent influenza virus vaccines. I. Observations on antibody response following vaccination. Am J Hyg. 1952 Jan;55(1):1–11. doi: 10.1093/oxfordjournals.aje.a119498. [DOI] [PubMed] [Google Scholar]
  13. SALK J. E., BAILEY M. L., LAURENT A. M. The use of adjuvants in studies on influenza immunization. II. Increased antibody formation in human subjects inoculated with influenza virus vaccine in a water in-oil emulsion. Am J Hyg. 1952 May;55(3):439–456. doi: 10.1093/oxfordjournals.aje.a119534. [DOI] [PubMed] [Google Scholar]
  14. SALK J. E., CONTAKOS M., LAURENT A. M., SORENSEN M., RAPALSKI A. J., SIMMONS I. H., SANDBERG H. Use of adjuvants in studies on influenza immunization. III. Degree of persistence of antibody in human subjects two years after vaccination. J Am Med Assoc. 1953 Apr 4;151(14):1169–1175. doi: 10.1001/jama.1953.02940140013005. [DOI] [PubMed] [Google Scholar]
  15. SALK J. E., LAURENT A. M., BAILEY M. L. Direction of research on vaccination against influenza; new studies with immunologic adjuvants. Am J Public Health Nations Health. 1951 Jun;41(6):669–677. doi: 10.2105/ajph.41.6.669. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. SALK J. E., LAURENT A. M. The use of adjuvants in studies on influenza immunization. I. Measurements in monkeys of the dimensions of antigenicity of virus-mineral oil emulsions. J Exp Med. 1952 May 1;95(5):429–447. doi: 10.1084/jem.95.5.429. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Salk J. E., Pearson H. E., Brown P. N., Francis T. PROTECTIVE EFFECT OF VACCINATION AGAINST INDUCED INFLUENZA B. J Clin Invest. 1945 Jul;24(4):547–553. doi: 10.1172/JCI101634. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Stokes J., Chenoweth A. D., Waltz A. D., Gladen R. G., Shaw D. RESULTS OF IMMUNIZATION BY MEANS OF ACTIVE VIRUS OF HUMAN INFLUENZA. J Clin Invest. 1937 Mar;16(2):237–243. doi: 10.1172/JCI100853. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Stuart-Harris C. H. Influenza Epidemics and the Influenza Viruses-II. Br Med J. 1945 Feb 24;1(4390):251–257. doi: 10.1136/bmj.1.4390.251. [DOI] [PMC free article] [PubMed] [Google Scholar]

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