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. 1967;37(1):79–88.

WHO collaborative study on the sero-epidemiology of rubella

W E Rawls, J L Melnick, C M P Bradstreet, M Bailey, A A Ferris, N I Lehmann, F P Nagler, J Furesz, R Kono, M Ohtawara, P Halonen, J Stewart, J M Ryan, J Strauss, J Zdrazilek, J Leerhoy, H von Magnus, R Sohier, W Ferreira
PMCID: PMC2554213  PMID: 5300057

Abstract

Under the auspices of WHO an investigation was made by 9 laboratories in different parts of the world on the distribution of rubella antibodies in girls and women of child-bearing age. In the first part of the study the objective was to determine the reliability and reproducibility of the tests employed. It was found that there were no significant differences in the variability of the titres obtained in different laboratories when the results were compared with those obtained by repeatedly testing the same sera in one laboratory.

In the second part of the study sera were obtained from girls in schools and women attending clinics and health centres. They were not taken from random samples of the populations. In most of the studies the pattern of development of antibody was similar. About half the persons had antibody at 6-8 years of age and 80%-87% at 17-22 years of age, the percentage remaining relatively constant thereafter. The island populations of Trinidad and Jamaica and a rural area of Japan were, however, found to have significantly fewer women with antibodies than urban areas in Europe or the Americas.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRODY J. A., SEVER J. L., MCALISTER R., SCHIFF G. M., CUTTING R. RUBELLA EPIDEMIC ON ST. PAUL ISLAND IN THE PRIBILOFS, 1963. I. EPIDEMIOLOGIC, CLINICAL, AND SEROLOGIC FINDINGS. JAMA. 1965 Feb 22;191:619–623. doi: 10.1001/jama.1965.03080080009002. [DOI] [PubMed] [Google Scholar]
  2. Black F. L. Measles endemicity in insular populations: critical community size and its evolutionary implication. J Theor Biol. 1966 Jul;11(2):207–211. doi: 10.1016/0022-5193(66)90161-5. [DOI] [PubMed] [Google Scholar]
  3. GIVAN K. F., ROZEE K. R., RHODES A. J. INCIDENCE OF RUBELLA ANTIBODIES IN FEMALE SUBJECTS. Can Med Assoc J. 1965 Jan 16;92:126–128. [PMC free article] [PubMed] [Google Scholar]
  4. HOPPS H. E., BERNHEIM B. C., NISALAK A., TJIO J. H., SMADEL J. E. BIOLOGIC CHARACTERISTICS OF A CONTINUOUS KIDNEY CELL LINE DERIVED FROM THE AFRICAN GREEN MONKEY. J Immunol. 1963 Sep;91:416–424. [PubMed] [Google Scholar]
  5. Halonen P. D., Casey H. L., Stewart J. A., Hall A. D. Rubella complement fixing antigen prepared by alkaline extraction of virus grown in suspension culture of BHK-211 cells. Proc Soc Exp Biol Med. 1967 May;125(1):167–172. doi: 10.3181/00379727-125-32039. [DOI] [PubMed] [Google Scholar]
  6. Halonen P. E., Ryan J. M., Stewart J. A. Rubella hemagglutinin prepared with alkaline extraction of virus grown in suspension culture of BHK-21 cells. Proc Soc Exp Biol Med. 1967 May;125(1):162–167. doi: 10.3181/00379727-125-32038. [DOI] [PubMed] [Google Scholar]
  7. KISSLING R. E., REESE D. R. ANTI-RABIES VACCINE OF TISSUE CULTURE ORIGIN. J Immunol. 1963 Sep;91:362–368. [PubMed] [Google Scholar]
  8. Lundström R., Svedmyr A., Hagbard L., Kaijser K. Rubella immunity as related to age and history of overt disease. Acta Paediatr Scand. 1967 May;56(3):279–285. doi: 10.1111/j.1651-2227.1967.tb15378.x. [DOI] [PubMed] [Google Scholar]
  9. MCCARTHY K., TAYLOR-ROBINSON C. H., PILLINGER S. E. ISOLATION OF RUBELLA VIRUS FROM CASES IN BRITAIN. Lancet. 1963 Sep 21;2(7308):593–598. doi: 10.1016/s0140-6736(63)90393-3. [DOI] [PubMed] [Google Scholar]
  10. Marcus P. I., Carver D. H. Hemadsorption-negative plaque test: new assay for rubella virus revealing a unique interference. Science. 1965 Aug 27;149(3687):983–986. doi: 10.1126/science.149.3687.983. [DOI] [PubMed] [Google Scholar]
  11. NEVA F. A., WELLER T. H. RUBELLA INTERFERON AND FACTORS INFLUENCING THE INDIRECT NEUTRALIZATION TEST FOR RUBELLA ANTIBODY. J Immunol. 1964 Sep;93:466–473. [PubMed] [Google Scholar]
  12. PARKMAN P. D., MUNDON F. K., MCCOWN J. M., BUESCHER E. L. STUDIES OF RUBELLA. II. NEUTRALIZATION OF THE VIRUS. J Immunol. 1964 Oct;93:608–617. [PubMed] [Google Scholar]
  13. Rawls W. E., Desmyter J., Melnick J. L. Rubella virus neutralization by plaque reduction. Proc Soc Exp Biol Med. 1967 Jan;124(1):167–172. doi: 10.3181/00379727-124-31692. [DOI] [PubMed] [Google Scholar]
  14. Rawls W. E., Melnick J. L., Rosenberg H. S., Bayatpour M. Spontaneous virus carrier cultures and postmortem isolation of virus from infants with congenital rubella. Proc Soc Exp Biol Med. 1965 Dec;120(3):623–626. doi: 10.3181/00379727-120-30608. [DOI] [PubMed] [Google Scholar]
  15. SEVER J. L. Application of a microtechnique to viral serological investigations. J Immunol. 1962 Mar;88:320–329. [PubMed] [Google Scholar]
  16. SEVER J. L., FABIYI A., MCCALLIN P. F., CHU P. T., WEISS W., GILKESON M. R. RUBELLA ANTIBODY AMONG PREGNANT WOMEN IN HAWAII. Am J Obstet Gynecol. 1965 Aug 1;92:1006–1008. doi: 10.1016/0002-9378(65)90735-0. [DOI] [PubMed] [Google Scholar]
  17. SEVER J. L., SCHIFF G. M., BELL J. A., KAPIKIAN A. Z., HUEBNER R. J., TRAUB R. G. RUBELLA: FREQUENCY OF ANTIBODY AMONG CHILDREN AND ADULTS. Pediatrics. 1965 Jun;35:996–998. [PubMed] [Google Scholar]
  18. Schmidt N. J., Lennette E. H. Rubella complement-fixing antigens derived from the fluid and cellular phases of infected BHK-21 cells: extraction of cell-associated antigen with alkaline buffers. J Immunol. 1966 Dec;97(6):815–821. [PubMed] [Google Scholar]
  19. Stewart G. L., Parkman P. D., Hopps H. E., Douglas R. D., Hamilton J. P., Meyer H. M., Jr Rubella-virus hemagglutination-inhibition test. N Engl J Med. 1967 Mar 9;276(10):554–557. doi: 10.1056/NEJM196703092761006. [DOI] [PubMed] [Google Scholar]
  20. Vaheri A., Sedwick W. D., Plotkin S. A., Maes R. Cytopathic effect of rubella virus in RHK21 cells and growth to high titers in suspension culture. Virology. 1965 Oct;27(2):239–241. doi: 10.1016/0042-6822(65)90170-4. [DOI] [PubMed] [Google Scholar]

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