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. 1984 Jan;49(1):102–108. doi: 10.1128/jvi.49.1.102-108.1984

Localization and synthesis of an antigenic determinant of herpes simplex virus glycoprotein D that stimulates the production of neutralizing antibody.

G H Cohen, B Dietzschold, M Ponce de Leon, D Long, E Golub, A Varrichio, L Pereira, R J Eisenberg
PMCID: PMC255430  PMID: 6197535

Abstract

An antigenic determinant capable of inducing type-common herpes simplex virus (HSV)-neutralizing antibodies has been located on glycoprotein D (gD) of HSV type 1 (HSV-1). A peptide of 16 amino acids corresponding to residues 8 to 23 of the mature glycoprotein (residues 33 to 48 of the predicted gD-1 sequence) was synthesized. This peptide reacted with an anti-gD monoclonal antibody (group VII) previously shown to neutralize the infectivity of HSV-1 and HSV-2. The peptide was also recognized by polyclonal antibodies prepared against purified gD-1 but was less reactive with anti-gD-2 sera. Sera from animals immunized with the synthetic peptide reacted with native gD and neutralized both HSV-1 and HSV-2.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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