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. 1967;37(2):287–292.

Insecticide-resistance in Culex pipiens fatigans*

J R Busvine
PMCID: PMC2554329  PMID: 5300068

Abstract

The three main subspecies of the Culex pipiens complex—pipiens, fatigans and molestus—have similar “normal” levels of susceptibility to insecticides. C. p. fatigans larvae resemble those of anopheline mosquitos in sensitivity to dieldrin, but are more resistant to DDT; the adults are unusually resistant to chlorinated insecticides, but do not differ greatly from other species of mosquito in susceptibility to organophosphorus compounds.

There is evidence of conversion of DDT to DDE in C. p. fatigans and other mosquitos, but this may well not be the only cause of resistance. Dieldrin-resistance in C. p. fatigans involves cross-resistance to HCH, but at a considerably lower level; the mechanism of resistance is still obscure. Resistance to organophosphorus insecticides has been observed; the cross-resistance to diazinon indicates that the mechanism is not solely one of carboxy-esterase detoxication.

Mechanisms of inheritance of resistance have been investigated. The most recent results indicate the monofactorial inheritance of resistance by a single pair of nearly dominant genes on chromosome 2 for DDT-resistance and by a single pair of genes on chromosome 3 with intermediate dominance for HCH dieldrin-resistance.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BURNETT G. F., ASH L. H. The susceptibility to insecticides of disease-carrying mosquitos in Fiji. Bull World Health Organ. 1961;24:547–555. [PMC free article] [PubMed] [Google Scholar]
  2. DAVIDSON G. DDT-RESISTANCE AND DIELDRIN-RESISTANCE IN CULEX PIPIENS FATIGANS WIEDEMANN. Ann Trop Med Parasitol. 1964 Jun;58:180–188. doi: 10.1080/00034983.1964.11686229. [DOI] [PubMed] [Google Scholar]
  3. Georghiou G. P. Development and characterization of resistance to o-isopropoxyphenyl methylcarbamate in the mosquito Culex pipiens quinquefasciatus Say. Nature. 1965 Aug 21;207(999):883–884. doi: 10.1038/207883a0. [DOI] [PubMed] [Google Scholar]
  4. HAMON J., SALES S. SENSIBILIT'E AU MALATHION ET AU FENTHION (BAYTEX) D' "A. GAMBIAE", "A. FUNESTUS", "A. RUFIPES", "AE. AEGYPTI", "C.P. FATIGANS", "M. UNIFORMIS" ET "M. AFRICANA". ETUDE DE LA STABILITE DES PAPIERS IMPREGNES DE SOLUTIONS HUILEUSES DE CES INSECTICIDES. Med Trop (Mars) 1963 Sep-Oct;23:621–635. [PubMed] [Google Scholar]
  5. KIMURA T., DUFFY J. R., BROWN A. W. DEHYDROCHLORINATION AND DDT-RESISTANCE IN CULEX MOSQUITOS. Bull World Health Organ. 1965;32:557–561. [PMC free article] [PubMed] [Google Scholar]
  6. MOUCHET J., ELLIOT R., GARIOU J., VOELCKEL J., VARRIERAS J. [Resistance to insecticides in Culex pipiens fatigans Wied. and problems of urban hygiene in the Cameroons]. Med Trop (Mars) 1960 Jul-Aug;20:447–456. [PubMed] [Google Scholar]
  7. PAL R., SINGH N. N. Inheritance of D.D.T.-resistance in Culex fatigans. Indian J Malariol. 1958 Dec;12:499–516. [PubMed] [Google Scholar]
  8. PENNELL J. T., HOSKINS W. M. THE MONOFACTORIAL INHERITANCE OF RESISTANCE TO DIELDRIN IN LARVAL AND ADULT CULEX QUINQUEFASCIATUS SAY. Bull World Health Organ. 1964;31:669–677. [PMC free article] [PubMed] [Google Scholar]
  9. ROZEBOOM L. E. Inheritance of DDT resistance in a Philippine population of Culex pipiens fatigans Wied. Bull World Health Organ. 1960;22:587–590. [PMC free article] [PubMed] [Google Scholar]
  10. SMITH A., BRANSBY-WILLIAMS W. R. The susceptibility of Culex pipiens fatigans to residual insecticides with particular reference to the Taveta-Pare area of East Africa. Bull World Health Organ. 1962;27:603–607. [PMC free article] [PubMed] [Google Scholar]

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