Abstract
Simian virus 40 small-t antigen allows the growth of CV-1 cells in concentrations of theophylline that normally prevent cell cycling. This effect is completely overcome by two ionophores that uncouple mitochondria and by the anti-mitochondrial drug methylglyoxal bis-(guanylhydrazone).
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ball E. H., Singer S. J. Mitochondria are associated with microtubules and not with intermediate filaments in cultured fibroblasts. Proc Natl Acad Sci U S A. 1982 Jan;79(1):123–126. doi: 10.1073/pnas.79.1.123. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bouck N., Beales N., Shenk T., Berg P., di Mayorca G. New region of the simian virus 40 genome required for efficient viral transformation. Proc Natl Acad Sci U S A. 1978 May;75(5):2473–2477. doi: 10.1073/pnas.75.5.2473. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Burckhardt G., Pietrzyk C. The influence of an uncoupler on amino acid accumulation in Ehrlich mouse ascites tumor cells. Biochim Biophys Acta. 1980 Sep 18;601(2):403–414. doi: 10.1016/0005-2736(80)90544-1. [DOI] [PubMed] [Google Scholar]
- Byczkowski J. Z., Salamon W., Harlos J. P., Porter C. W. Actions of bis(guanylhydrazones) on isolated rat liver mitochondria. Biochem Pharmacol. 1981 Oct;30(20):2851–2860. doi: 10.1016/0006-2952(81)90425-1. [DOI] [PubMed] [Google Scholar]
- Fillingame R. H., Morris D. R. S-adenosyl-L-methionine decarboxylase during lymphocyte transformation: decreased degradation in the presence of a specific inhibitor. Biochem Biophys Res Commun. 1973 Jun 8;52(3):1020–1025. doi: 10.1016/0006-291x(73)91039-5. [DOI] [PubMed] [Google Scholar]
- Graessmann A., Graessmann M., Tjian R., Topp W. C. Simian virus 40 small-t protein is required for loss of actin cable networks in rat cells. J Virol. 1980 Mar;33(3):1182–1191. doi: 10.1128/jvi.33.3.1182-1191.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hirt B. Selective extraction of polyoma DNA from infected mouse cell cultures. J Mol Biol. 1967 Jun 14;26(2):365–369. doi: 10.1016/0022-2836(67)90307-5. [DOI] [PubMed] [Google Scholar]
- Lever J. E. Membrane potential and neutral amino acid transport in plasma membrane vesicles from Simian virus 40 transformed mouse fibroblasts. Biochemistry. 1977 Sep 20;16(19):4328–4334. doi: 10.1021/bi00638a031. [DOI] [PubMed] [Google Scholar]
- Martin R. G., Setlow V. P., Edwards C. A., Vembu D. The roles of the simian virus 40 tumor antigens in transformation of Chinese hamster lung cells. Cell. 1979 Jul;17(3):635–643. doi: 10.1016/0092-8674(79)90271-x. [DOI] [PubMed] [Google Scholar]
- Mose-Larsen P., Bravo R., Fey S. J., Small J. V., Celis J. E. Putative association of mitochondria with a subpopulation of intermediate-sized filaments in cultured human skin fibroblasts. Cell. 1982 Dec;31(3 Pt 2):681–692. doi: 10.1016/0092-8674(82)90323-3. [DOI] [PubMed] [Google Scholar]
- Pine M. J., DiPaolo J. A. The antimitochondrial action of 2-choloro-4', 4"-bis(2-imidazolin-2-yl)terephthalanilide and methylglyoxal bis(guanylhydrazone). Cancer Res. 1966 Jan;26(1):18–25. [PubMed] [Google Scholar]
- Rundell K., Cox J. Simian virus 40 t antigen affects the sensitivity of cellular DNA synthesis to theophylline. J Virol. 1979 Apr;30(1):394–396. doi: 10.1128/jvi.30.1.394-396.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sleigh M. J., Topp W. C., Hanich R., Sambrook J. F. Mutants of SV40 with an altered small t protein are reduced in their ability to transform cells. Cell. 1978 May;14(1):79–88. doi: 10.1016/0092-8674(78)90303-3. [DOI] [PubMed] [Google Scholar]
- Smith J. B., Rozengurt E. Serum stimulates the Na+,K+ pump in quiescent fibroblasts by increasing Na+ entry. Proc Natl Acad Sci U S A. 1978 Nov;75(11):5560–5564. doi: 10.1073/pnas.75.11.5560. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Soprano K. J., Galanti N., Jonak G. J., McKercher S., Pipas J. M., Peden K. W., Baserga R. Mutational analysis of simian virus 40 T antigen: stimulation of cellular DNA synthesis and activation of rRNA genes by mutants with deletions in the T-antigen gene. Mol Cell Biol. 1983 Feb;3(2):214–219. doi: 10.1128/mcb.3.2.214. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yang Y. C., Hearing P., Rundell K. Cellular proteins associated with simian virus 40 early gene products in newly infected cells. J Virol. 1979 Oct;32(1):147–154. doi: 10.1128/jvi.32.1.147-154.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]